Substance / Medication

Doxylamine

SNOMED 44068004 UMLS C0013092

Overview

Active Ingredient

doxylamine

RxNorm CUI

3642

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Disorders of initiating and maintaining sleep

Nonseasonal allergic rhinitis

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Alternative Sedation During Bronchoscopy

NCT01158820Phase 4Completed50 enrolled

View all 1 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Re-analysis of safety data supporting doxylamine use for nausea and vomiting of pregnancy.

Chin Jessica W S, Gregor Sarah, Persaud Navindra · Am J Perinatol · 2014

PMID: 24323370Meta-Analysis

Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 22 Factorial Trial.

Wu Xiao-Ke, Gao Jing-Shu, Ma Hong-Li et al. · Ann Intern Med · 2023

PMID: 37335994RCT

Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis.

Persaud Navindra, Meaney Christopher, El-Emam Khaled et al. · PLoS One · 2018

PMID: 29342163RCTFull text (PMC)

Effectiveness of doxylamine-pyridoxine for morning sickness.

Koren Gideon, Hankins Gary D V, Clark Shannon et al. · Am J Obstet Gynecol · 2016

PMID: 26844757RCT

Pharmacokinetic dose proportionality between two strengths (12.5 mg and 25 mg) of doxylamine hydrogen succinate film-coated tablets in fasting state: a single-dose, randomized, two-period crossover study in healthy volunteers.

Videla Sebastián, Cebrecos Jesús, Lahjou Mounia et al. · Drugs R D · 2013

PMID: 23633146RCTFull text (PMC)

A simple and sensitive LC-MS/MS method for determination of doxylamine in human plasma and its application in a bioequivalence study in healthy Chinese volunteers.

Fu Rong, Sheng Mang, Yang Can et al. · J Pharm Biomed Anal · 2022

PMID: 35994945Observational

[The interesting anti-H1 effects in maintenance insomnia: A reflection on the comparative advantages of doxylamine and doxepin].

Dupuis G, Vaugeois J-M · Encephale · 2020

PMID: 30879783Observational

The effect of early urine alkalinization on occurrence rhabdomyolysis and hospital stay in high dose doxylamine ingestion.

Kim Eun, Choi Yoon Hee, Lim Ji Yeon et al. · Am J Emerg Med · 2018

PMID: 29196111Observational

8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information.

Zhang Rujun, Persaud Navindra · PLoS One · 2017

PMID: 28052111ObservationalFull text (PMC)

Comparing pyridoxine and doxylamine succinate-pyridoxine HCl for nausea and vomiting of pregnancy: A matched, controlled cohort study.

Pope Eliza, Maltepe Caroline, Koren Gideon · J Clin Pharmacol · 2015

PMID: 25663469Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Doxylamine (substance)
SNOMED CT: 44068004
UMLS CUI: C0013092
RxNorm CUI: 3642

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.