Substance / Medication

Esomeprazole magnesium

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Esophagitis

Duodenal ulcer disease

Zollinger-Ellison syndrome

Gastroesophageal reflux disease

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:

Variants in the PSCA gene associated with risk of cancer and nonneoplastic diseases: systematic research synopsis, meta-analysis and epidemiological evidence.

Cui Huijie, Tang Mingshuang, Zhang Min et al. · Carcinogenesis · 2019

PMID: 30407486Meta-Analysis

Laparoscopic Repair for Perforated Peptic Ulcer Disease Has Better Outcomes Than Open Repair.

Quah Gaik S, Eslick Guy D, Cox Michael R · J Gastrointest Surg · 2019

PMID: 30465190Meta-Analysis

Pharmacokinetics of Esomeprazole Magnesium After Single Oral Doses in Healthy Subjects: Bioequivalence Study and Food Effects.

Zhong Xue-Feng, Zhou Gan, Xu Su-Mei et al. · Clin Pharmacol Drug Dev · 2022

PMID: 35822412RCT

Comparison of esomeprazole enteric-coated capsules vs esomeprazole magnesium in the treatment of active duodenal ulcer: a randomized, double-blind, controlled study.

Liang Xiao-Yan, Gao Qing, Gong Neng-Ping et al. · World J Gastroenterol · 2008

PMID: 18350637RCTFull text (PMC)

Evaluation of the Pharmacokinetic Interaction and Safety of Ubrogepant Coadministered With Esomeprazole Magnesium.

Boinpally Ramesh, Lu Kaifeng · Clin Pharmacol Drug Dev · 2022

PMID: 34811955Trial

Impact of concomitant low-dose aspirin on the safety and tolerability of naproxen and esomeprazole magnesium delayed-release tablets in patients requiring chronic nonsteroidal anti-inflammatory drug therapy: an analysis from 5 Phase III studies.

Angiolillo Dominick J, Datto Catherine, Raines Shane et al. · J Thromb Thrombolysis · 2014

PMID: 24368727Trial

Impact of a fixed-dose combination of naproxen and esomeprazole magnesium on serum thromboxane B2 inhibition by low-dose aspirin over 5 days in healthy adults: a phase I, randomized, double-blind, placebo-controlled, noninferiority trial.

Angiolillo Dominick J, Hwang Clara, Datto Catherine et al. · Clin Ther · 2011

PMID: 22078153Trial

Long-term safety of naproxen and esomeprazole magnesium fixed-dose combination: phase III study in patients at risk for NSAID-associated gastric ulcers.

Sostek Mark B, Fort John G, Estborn Lennart et al. · Curr Med Res Opin · 2011

PMID: 21319944Trial

A fixed-dose combination of naproxen and esomeprazole magnesium has comparable upper gastrointestinal tolerability to celecoxib in patients with osteoarthritis of the knee: results from two randomized, parallel-group, placebo-controlled trials.

Cryer Byron L, Sostek Mark B, Fort John G et al. · Ann Med · 2011

PMID: 22017620Trial

Clinical trial: evaluation of gastric acid suppression with three doses of immediate-release esomeprazole in the fixed-dose combination of PN 400 (naproxen/esomeprazole magnesium) compared with naproxen 500 mg and enteric-coated esomeprazole 20 mg: a randomized, open-label, Phase I study in healthy volunteers.

Miner P, Plachetka J, Orlemans E et al. · Aliment Pharmacol Ther · 2010

PMID: 20491746Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Esomeprazole magnesium (substance)
SNOMED CT: 129489006
UMLS CUI: C0937622

Clinical Data

This intervention maps to 4 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.