Substance / Medication

Flucytosine

Overview

Active Ingredient
flucytosine
RxNorm CUI
4451

Indications

Candida Cryptococcus Flucytosine Capsules USP is indicated only in the treatment of serious infections caused by susceptible strains ofand/or. Candida: Septicemia, endocarditis and urinary system infections have been effectively treated with flucytosine. Limited trials in pulmonary infections justify the use of flucytosine. Cryptococcus: Meningitis and pulmonary infections have been treated effectively. Studies in septicemias and urinary tract infections are limited, but good responses have been

Labeler: AvPAKUpdated: 2026-01-08T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

Use with extreme caution in patients with impaired renal function. Close monitoring of hematologic, renal and hepatic status of all patients is essential. These instructions should be thoroughly reviewed before administration of Flucytosine Capsules USP.

Contraindications

When this intervention should not be used

Flucytosine Capsules USP should not be used in patients with a known hypersensitivity to the drug.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Cryptococcosis in pregnancy and the postpartum period: Case series and systematic review with recommendations for management.
Pastick Katelyn A, Nalintya Elizabeth, Tugume Lillian et al. · Med Mycol · 2020
PMID: 31689712Meta-AnalysisFull text (PMC)
High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: a randomized trial.
Bicanic Tihana, Wood Robin, Meintjes Graeme et al. · Clin Infect Dis · 2008
PMID: 18505387RCT
Vectorized gene therapy of liver tumors: proof-of-concept of TG4023 (MVA-FCU1) in combination with flucytosine.
Husseini F, Delord J-P, Fournel-Federico C et al. · Ann Oncol · 2017
PMID: 28177438Trial
[Evaluation of low-dose amphotericin B and flucytosine in the treatment of cryptococcal meningitis].
Xu Bin, Wu Ji-qin, Ou Xue-ting et al. · Zhonghua Yi Xue Za Zhi · 2010
PMID: 20367933Trial
Fluconazole alone or combined with flucytosine for the treatment of AIDS-associated cryptococcal meningitis.
Milefchik Eric, Leal Mary Ann, Haubrich Richard et al. · Med Mycol · 2008
PMID: 18415850Trial
Flucytosine and cryptococcosis: which in vitro test is the best predictor of outcome?
Viviani M A, Esposto M C, Cogliati M et al. · J Chemother · 2003
PMID: 12797387Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Flucytosine (substance)
SNOMED CT
387155003
UMLS CUI
C0016278
RxNorm CUI
4451
Labeler
AvPAK

Clinical Data

This intervention maps to 4 entities in the Ltrl knowledge graph.

4
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.