Back to Interventions
Substance / Medication

Guaifenesin

SNOMED 87174009UMLS C0018305

Overview

Active Ingredient
guaifenesin
RxNorm CUI
5032

Indications

helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive

Labeler: Bryant Ranch PrepackUpdated: 2025-06-02T00:00:00.000ZFull label on DailyMed

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Pertussis
Bronchitis
Sinusitis
Laryngitis
Common cold
Pharyngitis
Nonseasonal allergic rhinitis

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

14 trials linked to this intervention

14
Total Trials
1
Recruiting
1
With Results

Recent Trials

Recurrent Throat Infections and Tonsillectomy

NCT00547391Phase 4Completed87 enrolled

Post Operative Sore Throat and Dexamethasone

NCT01052038Phase 4Completed120 enrolled

Efficacy of Tinoridine in Treating Pain and Inflammation in Adults

NCT01224756Phase 4Completed342 enrolled

Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies

NCT01363531Phase 4Completed405 enrolled

Impact of Four Patient Information Leaflets (PIL) on Patient Behaviour

NCT01398696Phase 4Completed400 enrolled
View all 14 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:
Ephedrine- and guaifenesin-induced nephrolithiasis.
Bennett Stephen, Hoffman Nathan, Monga Manoj · J Altern Complement Med · 2004
PMID: 15673990Meta-Analysis
[Evaluation of the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol versus a fixed-dose combination of bromhexine/guaifenesin/salbutamol in the treatment of productive cough in adult patients with acute bronchitis].
Zaitsev A A, Leshchenko I V, Esaulova N A et al. · Ter Arkh · 2023
PMID: 37167145RCT
Evaluation of total intravenous anesthesia with propofol-guaifenesin-medetomidine and alfaxalone-guaifenesin-medetomidine in Thoroughbred horses undergoing castration.
Aoki Motoki, Wakuno Ai, Kushiro Asuka et al. · J Vet Med Sci · 2017
PMID: 29057764RCTFull text (PMC)
Pharmacokinetics of guaifenesin, pseudoephedrine and hydrocodone in a combination oral liquid formulation, administered as single and multiple doses in healthy Chinese volunteers, and comparison with data for individual compounds formulated as Antuss®.
Deng Shuhua, Huang Wencan, Ni Xiaojia et al. · Xenobiotica · 2017
PMID: 27662264RCT
Alfaxalone compared with ketamine for induction of anaesthesia in horses following xylazine and guaifenesin.
Keates Helen L, van Eps Andrew W, Pearson Martin R B · Vet Anaesth Analg · 2012
PMID: 22823480RCT
Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough.
Dicpinigaitis Peter V, Gayle Yvonne E, Solomon Gail et al. · Respir Med · 2009
PMID: 19121573RCT
Effects of changing body position on oxygenation and arterial blood pressures in foals anesthetized with guaifenesin, ketamine, and xylazine.
Braun Christina, Trim Cynthia M, Eggleston Randy B · Vet Anaesth Analg · 2009
PMID: 19121155RCT
Simultaneous determination of dextromethorphan, dextrorphan, and guaifenesin in human plasma using semi-automated liquid/liquid extraction and gradient liquid chromatography tandem mass spectrometry.
Eichhold Thomas H, McCauley-Myers David L, Khambe Deepa A et al. · J Pharm Biomed Anal · 2007
PMID: 16930908RCT
A pilot study of safety of sulfamethoxazole, trimethoprim and guaifenesin in pediatric and adult patients with acute bronchitis.
Falcon Mayer, Iberico Carlos, Guerra Frances et al. · BMC Res Notes · 2019
PMID: 30832720ObservationalFull text (PMC)
RP-HPLC-UV method development and validation for simultaneous determination of terbutaline sulphate, ambroxol HCl and guaifenesin in pure and dosage forms.
Itagimatha N, Manjunatha D H · Ann Pharm Fr · 2019
PMID: 31027752Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Guaifenesin (substance)
SNOMED CT
87174009
UMLS CUI
C0018305
RxNorm CUI
5032
Labeler
Bryant Ranch Prepack

Clinical Data

This intervention maps to 7 entities in the Healos knowledge graph.

7
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
14
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.