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Substance / Medication

Imipenem

SNOMED 46558003UMLS C0020933

Overview

Active Ingredient
imipenem
RxNorm CUI
5690

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Staphylococcal infectious disease
Pseudomonas infection
Urinary tract infectious disease
Streptococcal infectious disease
Bacterial infectious disease
Systemic infection
Infectious disease of abdomen
Infection caused by Enterobacteriaceae
Infection of pelvis
Respiratory tract infection
Bacterial endocarditis

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

8 trials linked to this intervention

8
Total Trials
0
Recruiting
1
With Results

Recent Trials

Antibiotic Prophylaxis for Transrectal Prostate Biopsy

NCT01659866Phase 4Completed563 enrolled

Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis

NCT00871104Phase 4Completed50 enrolled

Pharmacodynamics Study of Imipenem in Patients With Ventilator Associated Pneumonia

NCT01379157Phase 4Completed8 enrolled

Imipenem Prophylaxis in Patients With Acute Pancreatitis

NCT02897206Phase 4Completed98 enrolled

A De-Escalating Strategy for Antibiotic Treatment of Pneumonia in The Medical Intensive Care Unit (0787B-092)

NCT00445094Phase 4Completed120 enrolled
View all 8 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy and safety of imipenem/cilastatin/relebactam (IMI/CS/REL): a meta-analysis of randomized controlled clinical trials.
Lei Wenjuan, Duan Yan, Xin Mingyan et al. · BMC Infect Dis · 2025
PMID: 41013394Meta-AnalysisFull text (PMC)
Effects of imipenem combined with glutamine in the treatment of severe acute pancreatitis with abdominal infection in mainland China: a meta-analysis.
Zhou Shuang, Jin Lai-Run, He Chiyi · Rev Assoc Med Bras (1992) · 2022
PMID: 35442370Meta-Analysis
Imipenem resistance of Pseudomonas in pneumonia: a systematic literature review.
Zilberberg Marya D, Chen Joyce, Mody Samir H et al. · BMC Pulm Med · 2010
PMID: 20796312Meta-AnalysisFull text (PMC)
Using imipenem and cilastatin during continuous renal replacement therapy.
Cotton Alison, Franklin Bryony Dean, Brett Stephen et al. · Pharm World Sci · 2005
PMID: 16341743Meta-Analysis
A randomized non-inferiority study comparing imipenem/cilastatin/relebactam with standard-of-care Gram-negative coverage in cancer patients with febrile neutropenia.
Chaftari Anne-Marie, Dagher Hiba, Hachem Ray et al. · J Antimicrob Chemother · 2024
PMID: 39092963RCT
GAUCHO - Trial Genicular Artery Embolization Using Imipenem/Cilastatin vs. Microsphere for Knee Osteoarthritis: A Randomized Controlled Trial.
Correa Mateus Picada, Motta-Leal-Filho Joaquim M, Lugokeski Ricardo et al. · Cardiovasc Intervent Radiol · 2022
PMID: 35304614RCT
Pharmacokinetics and Tolerability of Intravenous Sulbactam-Durlobactam with Imipenem-Cilastatin in Hospitalized Adults with Complicated Urinary Tract Infections, Including Acute Pyelonephritis.
Sagan Olexiy, Yakubsevitch Ruslan, Yanev Krassimir et al. · Antimicrob Agents Chemother · 2020
PMID: 31843995RCTFull text (PMC)
Comparable Effect of Two-Step Versus Extended Infusions on the Pharmacokinetics of Imipenem in Patients with Sepsis and Septic Shock.
Huang Yingzi, Xu Kang, Zhan Ying et al. · Adv Ther · 2020
PMID: 32277344RCTFull text (PMC)
Impact of tigecycline versus imipenem-cilastatin on fibrinogen levels following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC): a randomized-controlled study.
Hakeam Hakeam A, Al Duhailib Zainab, Salahuddin Nawal et al. · J Chemother · 2018
PMID: 29565228RCT
A randomized open label study of 'imipenem vs. cefepime' in spontaneous bacterial peritonitis.
Jindal Ankur, Kumar Manoj, Bhadoria Ajeet S et al. · Liver Int · 2016
PMID: 26474358RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Imipenem (substance)
SNOMED CT
46558003
UMLS CUI
C0020933
RxNorm CUI
5690

Clinical Data

This intervention maps to 11 entities in the Healos knowledge graph.

11
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
8
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.