Overview
Indications
Indomethacin extended-release capsules are indicated for:• Moderate to severe rheumatoid arthritis including acute flares of chronic disease• Moderate to severe ankylosing spondylitis• Moderate to severe osteoarthritis• Acute painful shoulder (bursitis and/or tendinitis)
Boxed Warning
FDA Black Box Warning
Cardiovascular Thrombotic Events Warnings and Precautions (5.1) [see]. Contraindications (4) Warnings and Precautions (5.1) [seeand]. Gastrointestinal Bleeding, Ulceration, and Perforation Warnings and Precautions (5.2) [see]. • Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased ri
Contraindications
When this intervention should not be used
Warnings and Precautions (5.7 5.9 [see,)] Warnings and Precautions (5.7 5.8) [see,] Warnings and Precautions (5.1) [see] Indomethacin extended-release capsules are contraindicated in the following patients:• Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to indometh
Indications & Related Conditions
Conditions associated via SNOMED clinical relationships
Administration & Protocol
Dosing, route, and treatment protocol
Detailed dosage and administration information is available in the full FDA drug label.
View full prescribing information on DailyMedMonitoring & Follow-Up
Biomarkers relevant to this intervention via related conditions
Clinical Trials
17 trials linked to this intervention
Recent Trials
Arthroscopy and Manipulation vs a Home Therapy Program in the Treatment of Adhesive Capsulitis
Ibuprofen and Renal Function in Premature Infants
Comparative Study of Efficacy and Safety of Oral Ibuprofen and Intravenous Ibuprofen in Closure of Patent Ductus Arteriosus in Very Low Birth Weight Infants
Effectiveness of an Oxygen-nitrous Oxide Mixture During Physical Therapy for Frozen Shoulder
Oral Paracetamol Versus Oral Ibuprofen in Management of Patent Ductus Arteriosus in Preterm Infants: A Randomised Controlled Trial
Research Evidence
Published studies and systematic reviews
Research data from MEDLINE/PubMed
Benefits & Expected Outcomes
Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.
Risks & Side Effects
Adverse reaction and safety data for this drug is sourced from the FDA-approved label.
View adverse reactions & drug interactions on DailyMedRelated Symptoms
Symptoms associated with conditions this intervention addresses
No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.
Alternatives & Comparisons
Alternative treatments, comparison data, and clinical decision support are pending physician authorship.
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Do not start, stop, or change any treatment without consulting your healthcare provider.
Specialists
Providers who commonly manage this intervention
Quick Facts
- Type
- Substance / Medication
- Fully Specified Name
- Indometacin (substance)
- SNOMED CT
- 373513008
- UMLS CUI
- C0021246
- RxNorm CUI
- 5781
- Labeler
- Sportpharm LLC
Clinical Data
This intervention maps to 12 entities in the Healos knowledge graph.
Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.