Substance / Medication

Ketamine

Overview

Active Ingredient
ketamine
RxNorm CUI
6130

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
The effects of ketamine and esketamine on functional outcomes in major depressive disorder and treatment-resistant depression: A systematic review.
Ji Isabella S, Cheng Morgan C H, Teopiz Kayla M et al. · J Psychiatr Res · 2026
PMID: 41176897Meta-Analysis
A systematic review of ketamine's anxiolytic potential in rodent behavioral models of anxiety and PTSD.
Lemeshova Alena, Patel Kaya A, Bloom Alexander J et al. · Pharmacol Biochem Behav · 2026
PMID: 41391550Meta-Analysis
Ketamine and Esketamine for Late-Life Depression: A Systematic Review of Efficacy, Safety, and Tolerability.
Sukhdeo Ronesh, Tamura Jocelyn K, Dri Christine E et al. · Am J Geriatr Psychiatry · 2026
PMID: 40930887Meta-Analysis
Is ketamine safe for traumatic brain injury? A systematic review and meta-analysis.
Sciorilli João Vitor, Rossi Yohanna Idsabella, Dos Reis Schevz Rodrigo et al. · J Crit Care · 2026
PMID: 41197253Meta-Analysis
Effects of Intravenous Ketamine on Posttraumatic Stress Disorder (PTSD): A Systematic Review.
Yin Liyang, Lu Andy, Le Gia Han et al. · Acta Psychiatr Scand · 2026
PMID: 41326978Meta-AnalysisFull text (PMC)
Network Localization of Functional Brain Changes Associated With Ketamine's Therapeutic Effects in Depression.
Han Shaoqiang, Tian Ya, Yang Huiting et al. · Biol Psychiatry · 2026
PMID: 40518102Meta-Analysis
Ketamine-induced re-organisation of neural oscillations across health, MDD, and TRD: A systematic review of magnetoencephalography insights.
Zhang Xinbi, Huang Mingming, Xu Wangyang et al. · J Affect Disord · 2026
PMID: 40882850Meta-Analysis
Efficacy and safety of ketamine maintenance therapy in treatment-resistant depression: A systematic review of treatment protocols and clinical outcomes.
Al-Garni Abdulaziz M, Vazquez Gustavo, Alotibi Tariq et al. · J Affect Disord · 2026
PMID: 41109417Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Ketamine (substance)
SNOMED CT
373464007
UMLS CUI
C0022614
RxNorm CUI
6130

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.