Substance / Medication

Lomustine

Overview

Active Ingredient
lomustine
RxNorm CUI
6466
Labeler: Wilshire Pharmaceuticals, Inc.Updated: 2025-11-30T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

DELAYED MYELOSUPPRESSION lomustine lomustine 5.1 2.2 2.3 [see Warnings and Precautions (), Dosage and Administration (,)] Lomustine causes myelosuppression including fatal myelosuppression. Myelosuppression is delayed, dose-related, and cumulative; occurring 4 to 6 weeks after drug administration an

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Effectiveness of Lomustine Combined With Bevacizumab in Glioblastoma: A Meta-Analysis.
Ren Xing, Ai Di, Li Tong et al. · Front Neurol · 2020
PMID: 33551965Meta-AnalysisFull text (PMC)
Procarbazine, lomustine and vincristine for recurrent high-grade glioma.
Parasramka Saurabh, Talari Goutham, Rosenfeld Myrna et al. · Cochrane Database Syst Rev · 2017
PMID: 28744879Meta-AnalysisFull text (PMC)
Thrombocytopenia limits the feasibility of salvage lomustine chemotherapy in recurrent glioblastoma: a secondary analysis of EORTC 26101.
Le Rhun Emilie, Oppong Felix Boakye, van den Bent Martin et al. · Eur J Cancer · 2023
PMID: 36379185RCT
Lomustine is beneficial to older AML with ELN2017 adverse risk profile and intermediate karyotype: a FILO study.
Largeaud Laetitia, Cornillet-Lefebvre Pascale, Hamel Jean-François et al. · Leukemia · 2021
PMID: 32943750RCT
Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH.
Cairncross J Gregory, Wang Meihua, Jenkins Robert B et al. · J Clin Oncol · 2014
PMID: 24516018RCTFull text (PMC)
Prophylactic Antimicrobials for Prevention of Febrile Neutropenia in Tumour-Bearing Dogs Treated With Lomustine.
Gumash Meredith, Martin Olya A, Lindley Stephanie E S et al. · Vet Comp Oncol · 2025
PMID: 39467014Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Lomustine (substance)
SNOMED CT
387227009
UMLS CUI
C0023972
RxNorm CUI
6466
Labeler
Wilshire Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 8 entities in the Healos knowledge graph.

8
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.