Substance / Medication

Mafenide

Overview

Active Ingredient
mafenide
RxNorm CUI
6572

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

23 trials linked to this intervention

23
Total Trials
1
Recruiting
6
With Results

Research Evidence

Published studies and systematic reviews

Sort:
In vitro toxicity and activity of Dakin's solution, mafenide acetate, and amphotericin B on filamentous fungi and human cells.
Barsoumian Alice, Sanchez Carlos J, Mende Katrin et al. · J Orthop Trauma · 2013
PMID: 23287750Observational
Allergic contact dermatitis to mafenide acetate: a case series and review of the literature.
Firoz Elnaz F, Firoz Bahar F, Williams James F et al. · J Drugs Dermatol · 2007
PMID: 17763614Case Report
Mafenide acetate allergy presenting as recurrent chondritis.
Pickus Evan J, Lionelli Gerald T, Charles E Woodall et al. · Ann Plast Surg · 2002
PMID: 11910229Case Report
The Antimicrobial Efficacy of Topically Applied Mafenide Acetate, Citric Acid and Wound Irrigation Solutions Lavanox and Prontosan against.
Bagheri Mahsa, Zoric Andreas, von Kohout Maria et al. · Antibiotics (Basel) · 2024
PMID: 38247601OtherFull text (PMC)
Cost Analysis of Pure Hypochlorous Acid Preserved Wound Cleanser versus Mafenide for the Irrigation of Burn Wounds.
Rizzo Evelyn J, Mallow Peter J, Noble Aidan Jeffrey et al. · Clinicoecon Outcomes Res · 2024
PMID: 39430729OtherFull text (PMC)
Improving the antimicrobial activity of old antibacterial drug mafenide: Schiff bases and their bioactivity targeting resistant pathogens.
Krátký Martin, Konečná Klára, Šimková Adéla et al. · Future Med Chem · 2023
PMID: 36891917Other
Phenylalanine conjugated supramolecular hydrogels developed from the mafenide and flurbiprofen multidrug for biological applications.
Manna Utsab, Roy Rajdip, Dutta Abhishek et al. · Org Biomol Chem · 2023
PMID: 36852913Other
Control of invasive Pseudomonas burn wound infection with mafenide acetate electrospun wound dressing.
Kiamco Mia Mae, Sebastian Eliza A, Karna S L Rajasekhar et al. · Burns · 2025
PMID: 40939300Preclinical
Supramolecular Gelators Derived from Fmoc-Amino Acid Conjugates of Mafenide for Treating Melanoma: Toward Developing Vehicle-Free Drug Delivery.
Roy Nabanita, Ghosh Subhajit, Dastidar Parthasarathi · ACS Appl Bio Mater · 2025
PMID: 40616518Preclinical
The effects of topical mafenide acetate application on skin graft survival in bacterial contaminated wounds.
Baver Acaban M, Sarı Alper, Demirbağ Hatice Oruç et al. · Burns · 2024
PMID: 37985270Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Mafenide (substance)
SNOMED CT
372876009
UMLS CUI
C0024452
RxNorm CUI
6572

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
23
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.