Substance / Medication

Mercaptopurine

Overview

Active Ingredient
mercaptopurine
RxNorm CUI
103
Labeler: Golden State Medical Supply, Inc.Updated: 2026-02-25T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis.
Hasskamp Johannes, Meinhardt Christian, Patton Petrease H et al. · Cochrane Database Syst Rev · 2025
PMID: 40013523Meta-AnalysisFull text (PMC)
Pancreatitis associated with azathioprine and 6-mercaptopurine use in Crohn's disease: a systematic review.
Gordon Morris, Grafton-Clarke Ciaran, Akobeng Anthony et al. · Frontline Gastroenterol · 2021
PMID: 35401955Meta-AnalysisFull text (PMC)
Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn's disease.
Gjuladin-Hellon Teuta, Iheozor-Ejiofor Zipporah, Gordon Morris et al. · Cochrane Database Syst Rev · 2019
PMID: 31425621Meta-AnalysisFull text (PMC)
Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis.
Timmer Antje, Patton Petrease H, Chande Nilesh et al. · Cochrane Database Syst Rev · 2016
PMID: 27192092Meta-AnalysisFull text (PMC)
Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease.
Chande Nilesh, Townsend Cassandra M, Parker Claire E et al. · Cochrane Database Syst Rev · 2016
PMID: 27783843Meta-AnalysisFull text (PMC)
Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease.
Chande Nilesh, Patton Petrease H, Tsoulis David J et al. · Cochrane Database Syst Rev · 2015
PMID: 26517527Meta-AnalysisFull text (PMC)
Risk of lymphoma in patients with inflammatory bowel disease treated with azathioprine and 6-mercaptopurine: a meta-analysis.
Kotlyar David S, Lewis James D, Beaugerie Laurent et al. · Clin Gastroenterol Hepatol · 2015
PMID: 24879926Meta-Analysis
Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn's disease.
Gordon Morris, Taylor Kelly, Akobeng Anthony K et al. · Cochrane Database Syst Rev · 2014
PMID: 25081347Meta-AnalysisFull text (PMC)
Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease.
Chande Nilesh, Tsoulis David J, MacDonald John K · Cochrane Database Syst Rev · 2013
PMID: 23633304Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Mercaptopurine (substance)
SNOMED CT
386835005
UMLS CUI
C0000618
RxNorm CUI
103
Labeler
Golden State Medical Supply, Inc.

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.