Substance / Medication

Metformin

Overview

Active Ingredient
metformin
RxNorm CUI
6809
Labeler: Truemed Group LLCUpdated: 2023-04-14T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

History of a serious hypersensitivity reaction to sitagliptin, such as anaphylaxis or angioedema. [See Warnings and Precautions (5.4); Adverse Reactions (6.2).]

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

903 trials linked to this intervention

903
Total Trials
103
Recruiting
282
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Effect of metformin on central arterial stiffness in individuals with type 2 diabetes mellitus: a systematic review and meta-analysis.
Weningtyas Anditri, Hose Victor Alvianoes Guterez, Ramadhiani Risa et al. · Diabetes Res Clin Pract · 2026
PMID: 41401897Meta-Analysis
Intrauterine metformin exposure and adiposity outcomes in children: a systematic review and meta-analysis.
Fu Jennifer, Tabbara Najla, Tomlinson George et al. · BMJ Open · 2025
PMID: 39779258Meta-AnalysisFull text (PMC)
Comparing psilocybin to metformin as neuroprotective agents against Parkinson's dementia: A systematic review of evidence and efficacy.
Ordovich-Clarkson Randall D, Jabbour Maurice, Pelayo Daniel Arteaga et al. · Prog Neuropsychopharmacol Biol Psychiatry · 2025
PMID: 39357666Meta-Analysis
Effect of metformin on incidence, recurrence, and mortality in prostate cancer patients: integrating evidence from real-world studies.
Liu Yuchen, Zhang Qingfang, Huang Xuan · Prostate Cancer Prostatic Dis · 2025
PMID: 39014063Meta-Analysis
Comparison of metformin with inositol versus metformin alone in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.
Kelly Francinny Alves, de Oliveira Macena Lôbo Artur, Cardoso Jorge Henrique Cavalcanti Orestes et al. · Endocrine · 2025
PMID: 39331347Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Metformin (substance)
SNOMED CT
372567009
UMLS CUI
C0025598
RxNorm CUI
6809
Labeler
Truemed Group LLC

Clinical Data

This intervention maps to 10 entities in the Healos knowledge graph.

1
Conditions
4
Biomarkers
3
Specialists
0
Symptoms
903
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.