Substance / Medication

Methyl salicylate

Overview

Active Ingredient

methyl salicylate

RxNorm CUI

29787

Indications

FOR THE TEMPORARY RELIEF OF MINOR ACHES AND PAINS OF MUSCLES AND JOINTS ASSOCIATED WITH ARTHRITIS, SIMPLE BACKACHE, STRAINS, SPRAINS, MUSCLE SORENESS AND STIFFNESS.

Labeler: 1ST MEDX LLCUpdated: 2026-01-08T00:00:00.000ZFull label on DailyMed

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Arthritis

Contusion

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

34 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Study of Alkaptonuria

NCT00005909Recruiting300 enrolled

Preference of Rheumatoid Arthritis (RA) Patients of Enbrel® (Etanercept) Auto-Injector Versus Enbrel® Pre-Filled Syringes

NCT00094341Phase 4Completed215 enrolled

Enbrel® in Psoriatic Arthritis

NCT00111124Phase 4Completed

Study Evaluating Etanercept and Methotrexate in Plaque Psoriasis

NCT00161655Phase 4Completed60 enrolled

Efficacy and Safety of Lumiracoxib 400 mg Once Daily in Acute Flares of Gout

NCT00170781Phase 4Completed234 enrolled

View all 34 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Comparing the effects of verbenone, methyl salicylate, and permethrin on attacks of ambrosia beetles (Coleoptera: Curculionidae Scolytinae) in ornamental nurseries.

Govindaraju Ramkumar, Joseph Shimat V · J Insect Sci · 2025

PMID: 39868733ObservationalFull text (PMC)

Postharvest treatments with γ-aminobutyric acid, methyl jasmonate, or methyl salicylate enhance chilling tolerance of blood orange fruit at prolonged cold storage.

Habibi Fariborz, Ramezanian Asghar, Rahemi Majid et al. · J Sci Food Agric · 2019

PMID: 31283020Observational

Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.

Pauwels Jochen, D'Autry Ward, Van den Bossche Larissa et al. · J Pharm Biomed Anal · 2012

PMID: 22094014Observational

Efficacy and safety profile of a topical methyl salicylate and menthol patch in adult patients with mild to moderate muscle strain: a randomized, double-blind, parallel-group, placebo-controlled, multicenter study.

Higashi Yoshinobu, Kiuchi Takehito, Furuta Kenichi · Clin Ther · 2010

PMID: 20171409Observational

Comparison of oral aspirin versus topical applied methyl salicylate for platelet inhibition.

Tanen David A, Danish D Christopher, Reardon Jacqueline M et al. · Ann Pharmacother · 2008

PMID: 18698012Observational

Does methyl salicylate, a component of herbivore-induced plant odour, promote sporulation of the mite-pathogenic fungus Neozygites tanajoae?

Hountondji Fabien C C, Hanna Rachid, Sabelis Maurice W · Exp Appl Acarol · 2006

PMID: 16680566Observational

Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity.

Forouhar Farhad, Yang Yue, Kumar Dhirendra et al. · Proc Natl Acad Sci U S A · 2005

PMID: 15668381ObservationalFull text (PMC)

From Chemical Burn to Below Knee Amputation: Amputation Secondary to Application of Over-the-Counter Topical Analgesic With Menthol and Methyl Salicylate.

Desai Rohan, Gutierrez Jesus, Cherukuri Sundar V et al. · Cureus · 2021

PMID: 35004014Case ReportFull text (PMC)

Accidental methyl salicylate poisoning in two adults.

Seneviratne M P, Karunarathne S, de Alwis A H et al. · Ceylon Med J · 2015

PMID: 26132187Case Report

Treatment of post-electroconvulsive therapy headache with topical methyl salicylate.

Logan Christopher J, Stewart Jonathan T · J ECT · 2012

PMID: 22622298Case Report

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Methyl salicylate (substance)
SNOMED CT: 386988003
UMLS CUI: C0066282
RxNorm CUI: 29787
Labeler: 1ST MEDX LLC

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.