Substance / Medication

Metronidazole

Overview

Active Ingredient
metronidazole
RxNorm CUI
6922

Indications

Symptomatic Trichomoniasis. T. vaginalis Metronidazole tablets are indicated for the treatment ofinfection in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures). Asymptomatic Trichomoniasis. T. vaginalis Metronidazole tablets are indicated in the treatment of asymptomaticinfection in females when the organism is associated with endocervicitis, cervicitis, or cervical erosion. Since there is evidence that pre

Labeler: BluePoint LaboratoriesUpdated: 2026-02-23T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

WARNING PRECAUTIONS INDICATIONS AND USAGE Metronidazole has been shown to be carcinogenic in mice and rats (see). Unnecessary use of the drug should be avoided. Its use should be reserved for the conditions described in thesection below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

150 trials linked to this intervention

150
Total Trials
32
Recruiting
27
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Metronidazole is an effective method of analgesia following haemorrhoidectomy: a systematic review and meta-analysis.
O'Mahony Aaron, Cullinane Carolyn, MacCurtain Benjamin M et al. · Int J Colorectal Dis · 2026
PMID: 41586878Meta-Analysis
Efficacy of metronidazole in reducing pain after hemorrhoidectomy: a meta-analysis of randomized controlled trials.
Dong Hui, Chen Wen-Xing, Li Yue-Juan et al. · BMC Surg · 2025
PMID: 40055703Meta-AnalysisFull text (PMC)
A systematic review and meta-analysis on the efficacy of carbapenems versus metronidazole combination therapy in patients infected with Bacteroides spp.
Kato Hideo, Hirai Jun, Takano Tomonori et al. · J Infect Chemother · 2025
PMID: 40154881Meta-Analysis
Clinical pharmacokinetics of metronidazole: a systematic review and meta-analysis.
Shahzad Iqra, Alasmari Mohammed S, Zamir Ammara et al. · Antimicrob Agents Chemother · 2025
PMID: 40741956Meta-AnalysisFull text (PMC)
Piperacillin/tazobactam versus ceftriaxone/metronidazole for children with perforated appendicitis: a systematic review and meta-analysis.
Armstrong Jennifer, Sriranjan Jhanahan, Briatico Daniel et al. · Pediatr Surg Int · 2025
PMID: 41186640Meta-Analysis
Tinidazole vs metronidazole for the treatment of bacterial vaginosis: a systematic review and meta-analysis.
Sobral Milene Vitória Sampaio, Soares Victor Gonçalves, Moreira João Lucas de Magalhães Leal et al. · Arch Gynecol Obstet · 2025
PMID: 39969560Meta-AnalysisFull text (PMC)
Topical versus oral metronidazole for post-haemorrhoidectomy pain: A systematic review and meta-analysis of randomized controlled trials.
Pompeu Bernardo Fontel, Garcia Giulia Luiza, Barone Gabriel Leal et al. · Colorectal Dis · 2025
PMID: 41319118Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Metronidazole (substance)
SNOMED CT
372602008
UMLS CUI
C0025872
RxNorm CUI
6922
Labeler
BluePoint Laboratories

Clinical Data

This intervention maps to 18 entities in the Healos knowledge graph.

18
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
150
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.