Substance / Medication

Midostaurin

Overview

Active Ingredient
midostaurin
RxNorm CUI
1919083
Labeler: Novartis Pharmaceuticals CorporationUpdated: 2025-06-18T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

[see Description (11)]. [see Adverse Reactions (6.1)]. RYDAPT is contraindicated in patients with hypersensitivity to midostaurin or to any of the excipientsHypersensitivity reactions have included anaphylactic shock, dyspnea, flushing, chest pain, and angioedema (e.g., swelling of the airways or to

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Indirect treatment comparisons of avapritinib versus midostaurin for patients with advanced systemic mastocytosis.
Pilkington Hollie, Smith Sarah, Roskell Neil et al. · Future Oncol · 2022
PMID: 35114819Meta-Analysis
Midostaurin reduces relapse in FLT3-mutant acute myeloid leukemia: the Alliance CALGB 10603/RATIFY trial.
Larson Richard A, Mandrekar Sumithra J, Huebner Lucas J et al. · Leukemia · 2021
PMID: 33654204RCTFull text (PMC)
Midostaurin after allogeneic stem cell transplant in patients with FLT3-internal tandem duplication-positive acute myeloid leukemia.
Maziarz Richard T, Levis Mark, Patnaik Mrinal M et al. · Bone Marrow Transplant · 2021
PMID: 33288862RCTFull text (PMC)
Midostaurin in Advanced Systemic Mastocytosis.
Chandesris Marie-Olivia, Damaj Gandhi, Canioni Danielle et al. · N Engl J Med · 2016
PMID: 27355555RCT
Comparison of two endogenous biomarkers of CYP3A4 activity in a drug-drug interaction study between midostaurin and rifampicin.
Dutreix Catherine, Lorenzo Sebastien, Wang Yanfeng · Eur J Clin Pharmacol · 2014
PMID: 24839948RCTFull text (PMC)
Dose- and time-dependent pharmacokinetics of midostaurin in patients with diabetes mellitus.
Wang Yanfeng, Yin Ophelia Q P, Graf Peter et al. · J Clin Pharmacol · 2008
PMID: 18508951RCT
Midostaurin shapes macroclonal and microclonal evolution of FLT3-mutated acute myeloid leukemia.
Joudinaud Romane, Boudry Augustin, Fenwarth Laurène et al. · Blood Adv · 2025
PMID: 39418643ObservationalFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Midostaurin (substance)
SNOMED CT
763613005
UMLS CUI
C0526371
RxNorm CUI
1919083
Labeler
Novartis Pharmaceuticals Corporation

Clinical Data

This intervention maps to 3 entities in the Healos knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.