Substance / Medication

Natamycin

Overview

Active Ingredient
natamycin
RxNorm CUI
7268

Indications

® Fusarium solani in vitro NATACYN(natamycin ophthalmic suspension) 5% is indicated for the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms includingkeratitis. As in other forms of suppurative keratitis, initial and sustained therapy of fungal keratitis should be determined by the clinical diagnosis, laboratory diagnosis by smear and culture of corneal scrapings and drug response. Whenever possible theactivity of natamycin against the responsible fu

Labeler: Eyevance Pharmaceuticals, LLCUpdated: 2025-11-05T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

® NATACYN(natamycin ophthalmic suspension) 5% is contraindicated in individuals with a history of hypersensitivity to any of its components.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

4 trials linked to this intervention

4
Total Trials
0
Recruiting
3
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Tea tree oil for Demodex blepharitis.
Savla Keyur, Le Jimmy T, Pucker Andrew D · Cochrane Database Syst Rev · 2020
PMID: 32589270Meta-AnalysisFull text (PMC)
Endophthalmitis in patients co-infected by HIV and sporotrichosis: a systematic review of published case reports.
Ramírez-Soto Max Carlos, Bonifaz Alexandro, Tirado-Sánchez Andrés · Eye (Lond) · 2018
PMID: 29880916Meta-AnalysisFull text (PMC)
Re-appraisal of topical 1% voriconazole and 5% natamycin in the treatment of fungal keratitis in a randomised trial.
Sharma Savitri, Das Sujata, Virdi Ajoy et al. · Br J Ophthalmol · 2015
PMID: 25740805RCT
The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole.
Prajna N Venkatesh, Krishnan Tiruvengada, Mascarenhas Jeena et al. · JAMA Ophthalmol · 2013
PMID: 23710492TrialFull text (PMC)
Comparison of topical itraconazole 1% with topical natamycin 5% for the treatment of filamentous fungal keratitis.
Kalavathy C M, Parmar Pragya, Kaliamurthy J et al. · Cornea · 2005
PMID: 15829804Trial
A randomised clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis.
Prajna N V, John R K, Nirmalan P K et al. · Br J Ophthalmol · 2003
PMID: 14507756TrialFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Natamycin (substance)
SNOMED CT
372712006
UMLS CUI
C0027444
RxNorm CUI
7268
Labeler
Eyevance Pharmaceuticals, LLC

Clinical Data

This intervention maps to 17 entities in the Ltrl knowledge graph.

17
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
4
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.