Substance / Medication

Nicotine polacrilex

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

169 trials linked to this intervention

169
Total Trials
46
Recruiting
58
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Weaning From Tobacco with Nicotine or Varenicline in Severe and Mild Tobacco Dependence—Findings of a Meta-Analysis.
Selbach Claudia, Siebel Christian, Lilienthal Jona et al. · Dtsch Arztebl Int · 2025
PMID: 39628402Meta-AnalysisFull text (PMC)
Pharmacological treatment for substance use disorder: A systematic review.
Mateu-Mollá Joaquín, Pérez-Gálvez Bartolomé, Villanueva-Blasco Víctor José · Addict Behav · 2025
PMID: 39793188Meta-Analysis
Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.
Toikumo Sylvanus, Jennings Mariela V, Pham Benjamin K et al. · Nat Hum Behav · 2024
PMID: 38632388Meta-AnalysisFull text (PMC)
Characterization of the Abuse Potential in Adult Smokers of a Novel Oral Tobacco Product Relative to Combustible Cigarettes and Nicotine Polacrilex Gum.
Liu Jianmin, Wang Jingzhu, Vansickel Andrea et al. · Clin Pharmacol Drug Dev · 2021
PMID: 33502815ObservationalFull text (PMC)
Nicotine delivery and subjective effects of Swedish portion snus compared with 4 mg nicotine polacrilex chewing gum.
Lunell Erik, Curvall Margareta · Nicotine Tob Res · 2011
PMID: 21454913Observational
Comparative efficacy of rapid-release nicotine gum versus nicotine polacrilex gum in relieving smoking cue-provoked craving.
Niaura Raymond, Sayette Michael, Shiffman Saul et al. · Addiction · 2005
PMID: 16277632Observational
Time course of nicotine and cotinine incorporation into samples of nonsmokers' beard hair following a single dose of nicotine polacrilex.
Bernert John T, Alexander Joseph R, Sosnoff Connie S et al. · J Anal Toxicol · 2011
PMID: 21219696Other
Pharmacokinetics of a nicotine polacrilex lozenge.
Choi Jae H, Dresler Carolyn M, Norton Michele R et al. · Nicotine Tob Res · 2003
PMID: 14577980Trial
The efficacy of computer-tailored smoking cessation material as a supplement to nicotine polacrilex gum therapy.
Shiffman S, Paty J A, Rohay J M et al. · Arch Intern Med · 2000
PMID: 10847261Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Nicotine polacrilex (substance)
SNOMED CT
77544001
UMLS CUI
C0068722

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
169
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.