Substance / Medication

Nisoldipine

Overview

Active Ingredient

nisoldipine

RxNorm CUI

7435

Indications

SULAR is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.

Labeler: Covis Pharma US, IncUpdated: 2023-01-24T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

SULAR is contraindicated in patients with known hypersensitivity to dihydropyridine calcium channel blockers.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

High blood pressure

Prinzmetal angina

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Renoprotective Effect of Nisoldipine and Lisinopril in Type 1 Diabetic Nephropathy

NCT00311870Phase 4Completed52 enrolled

View all 1 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Effect of nisoldipine and olmesartan on endothelium-dependent vasodilation in essential hypertensive patients.

Wei Duo, He Wan-Yuan, Lv Qian-Zhou · CNS Neurosci Ther · 2012

PMID: 22533725RCTFull text (PMC)

Pharmacokinetics of oral doses of telmisartan and nisoldipine, given alone and in combination, in patients with essential hypertension.

Bajcetic Milica, Benndorf Ralf A, Appel Daniel et al. · J Clin Pharmacol · 2007

PMID: 17322141RCT

Comparison of effects of nisoldipine-extended release and amlodipine in patients with systemic hypertension and chronic stable angina pectoris.

Pepine Carl J, Cooper-DeHoff Rhonda M, Weiss Robert J et al. · Am J Cardiol · 2003

PMID: 12565082Trial

Comparative efficacy and safety of nisoldipine extended-release (ER) and amlodipine (CESNA-III study) in African American patients with hypertension.

White William B, Saunders Elijah, Noveck Robert J et al. · Am J Hypertens · 2003

PMID: 12944032Trial

Long term effects of nisoldipine on the progression of coronary atherosclerosis and the occurrence of clinical events: the NICOLE study.

Dens J A, Desmet W J, Coussement P et al. · Heart · 2003

PMID: 12860866TrialFull text (PMC)

Dynamic and kinetic disposition of nisoldipine enantiomers in hypertensive patients presenting with type-2 diabetes mellitus.

Marques Maria Paula, Coelho Eduardo Barbosa, Dos Santos Neife Aparecida Guinaim et al. · Eur J Clin Pharmacol · 2002

PMID: 12483453Trial

Comparison of 24-hour blood pressure profiles in patients with hypertension who were switched from amlodipine to nisoldipine.

Lenz T L, Wurdeman R L, Hilleman D E · Pharmacotherapy · 2001

PMID: 11718496Trial

Usefulness of Nisoldipine for prevention of restenosis after percutaneous transluminal coronary angioplasty (results of the NICOLE study). NIsoldipine in COronary artery disease in LEuven.

Dens J A, Desmet W J, Coussement P et al. · Am J Cardiol · 2001

PMID: 11137829Trial

Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects.

Takanaga H, Ohnishi A, Murakami H et al. · Clin Pharmacol Ther · 2000

PMID: 10741622Trial

A comparison of nisoldipine ER and amlodipine for the treatment of mild to moderate hypertension.

Whitcomb C, Enzmann G, Pershadsingh H A et al. · Int J Clin Pract · 2000

PMID: 11198728Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Nisoldipine (substance)
SNOMED CT: 386861009
UMLS CUI: C0028116
RxNorm CUI: 7435
Labeler: Covis Pharma US, Inc

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.