Substance / Medication

Nitroglycerin

Overview

Active Ingredient
nitroglycerin
RxNorm CUI
4917

Indications

Nitroglycerin sublingual tablets are indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.

Labeler: HF Acquisition Co LLC, DBA HealthFirstUpdated: 2026-02-20T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

4.1 PDE-5-Inhibitors and sGC-Stimulators Do not use nitroglycerin in patients who are taking PDE-5 Inhibitors, such as avanafil, sildenafil, tadalafil, vardenafil hydrochloride. Concomitant use can cause severe hypotension, syncope, or myocardial ischemia [see Drug Interactions (7.1)]. Do not use ni

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

69 trials linked to this intervention

69
Total Trials
15
Recruiting
17
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Nitroglycerine for retained placenta: a meta-analysis of randomized controlled trials.
Petrecca Alessandro, Saccone Gabriele, Berghella Vincenzo · Am J Obstet Gynecol MFM · 2025
PMID: 39818273Meta-Analysis
Local nitroglycerin to facilitate radial arterial catheterization in adults: a systematic review and meta-analysis.
Rao Uday, Phillips Timothy, Rao Shripada · Can J Anaesth · 2025
PMID: 40108074Meta-Analysis
The effect of nitroglycerin treatment on cerebral ischaemia: A systematic review and meta-analysis of animal studies.
Litman Magdalena, Spratt Neil J, Beard Daniel J · Nitric Oxide · 2024
PMID: 39182717Meta-Analysis
Local nitroglycerin to facilitate peripheral arterial cannulation in children: systematic review and meta-analysis.
Wagh Deepika, Pawale Dinesh, Tan Jason Khay Ghim et al. · Arch Dis Child · 2022
PMID: 35595521Meta-Analysis
Topical nitroglycerin is associated with a reduced mastectomy skin flap necrosis-systematic review and meta-analysis.
Vania Rachel, Pranata Raymond, Irwansyah Denny et al. · J Plast Reconstr Aesthet Surg · 2020
PMID: 32146114Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Glyceryl trinitrate (substance)
SNOMED CT
387404004
UMLS CUI
C0017887
RxNorm CUI
4917
Labeler
HF Acquisition Co LLC, DBA HealthFirst

Clinical Data

This intervention maps to 18 entities in the Healos knowledge graph.

7
Conditions
7
Biomarkers
3
Specialists
0
Symptoms
69
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.