Substance / Medication

Oxybenzone

Overview

Active Ingredient

oxybenzone

RxNorm CUI

32673

Indications

Ombrelle’s patented filtering system with Mexoryl technology and other sunscreen filters provides effective broad-spectrum UVA/UVB protection and helps prevent sunburns.

Labeler: L'Oreal USA Products IncUpdated: 2026-01-07T00:00:00.000ZFull label on DailyMed

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Photodermatitis

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:

Rates of allergic sensitization and irritation to oxybenzone-containing sunscreen products: a quantitative meta-analysis of 64 exaggerated use studies.

Agin Patricia P, Ruble Karen, Hermansky Steven J et al. · Photodermatol Photoimmunol Photomed · 2008

PMID: 18717962Meta-Analysis

Novel simultaneous method for the determination of avobenzone and oxybenzone in human plasma by UHPLC-MS/MS with phospholipid removal pretreatment: An application to a sunscreen clinical trial.

Pilli Nageswara R, Narayanasamy Suresh, Florian Jeffry et al. · J Chromatogr B Analyt Technol Biomed Life Sci · 2021

PMID: 33706185RCT

Percutaneous permeation comparison of repellents picaridin and DEET in concurrent use with sunscreen oxybenzone from commercially available preparations.

Chen T, Burczynski F J, Miller D W et al. · Pharmazie · 2010

PMID: 21155391Observational

In vitro permeation of repellent DEET and sunscreen oxybenzone across three artificial membranes.

Wang Tao, Kasichayanula Sreeneeranj, Gu Xiaochen · Int J Pharm · 2006

PMID: 16414221Observational

Simultaneous analysis of insect repellent DEET, sunscreen oxybenzone and five relevant metabolites by reversed-phase HPLC with UV detection: application to an in vivo study in a piglet model.

Kasichayanula Sreeneeranj, House James D, Wang Tao et al. · J Chromatogr B Analyt Technol Biomed Life Sci · 2005

PMID: 15993660Observational

In-vitro permeation of the insect repellent N,N-diethyl-m-toluamide (DEET) and the sunscreen oxybenzone.

Gu Xiaochen, Kasichayanula Sreeneeranj, Fediuk Daryl J et al. · J Pharm Pharmacol · 2004

PMID: 15142339Observational

Efficient flow injection and sequential injection methods for spectrophotometric determination of oxybenzone in sunscreens based on reaction with Ni(II).

Chisvert A, Salvador A, Pascual-Martí M C et al. · Fresenius J Anal Chem · 2001

PMID: 11371073Observational

Photocontact allergy to oxybenzone and contact allergy to lignocaine and prilocaine.

Langan Sinead M, Collins Paul · Contact Dermatitis · 2006

PMID: 16524446Case Report

Photoallergic contact cheilitis due to oxybenzone found in a lip cosmetic.

Veysey E C, Orton D I · Contact Dermatitis · 2006

PMID: 16842557Case Report

Contact urticaria, allergic contact dermatitis, and photoallergic contact dermatitis from oxybenzone.

Landers Maeran, Law Sandra, Storrs Frances J · Am J Contact Dermat · 2003

PMID: 14744420Case Report

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Oxybenzone (substance)
SNOMED CT: 72179002
UMLS CUI: C0069803
RxNorm CUI: 32673
Labeler: L'Oreal USA Products Inc

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.