Substance / Medication

Pegaspargase

Overview

Active Ingredient
pegaspargase
RxNorm CUI
34132
Labeler: Servier Pharmaceuticals LLCUpdated: 2024-10-07T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

ONCASPAR is contraindicated in patients with a: Warnings and Precautions (5.1) [see] History of serious hypersensitivity reactions, including anaphylaxis, to ONCASPAR or to any of the excipients. Warnings and Precautions (5.2) [see] History of serious thrombosis with prior L-asparaginase therapy. Wa

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

2 trials linked to this intervention

2
Total Trials
1
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Pegaspargase hypersensitivity reactions: intravenous infusion versus intramuscular injection - a review.
Beaupin Lynda Kwon, Bostrom Bruce, Barth Matthew J et al. · Leuk Lymphoma · 2017
PMID: 27643446Meta-Analysis
Randomized, Parallel Group, Open-Label Bioequivalence Trial of Intramuscular Pegaspargase in Patients With Relapsed Acute Lymphoblastic Leukemia.
Nookala Krishnamurthy Manjunath, Narula Gaurav, Gandhi Khushboo et al. · JCO Glob Oncol · 2020
PMID: 32628582RCTFull text (PMC)
Dosing-related saturation of toxicity and accelerated drug clearance with pegaspargase treatment.
Liu Yiwei, Panetta John C, Yang Wenjian et al. · Blood · 2020
PMID: 32750103RCTFull text (PMC)
Higher Rates of Hypersensitivity Reactions to Calaspargase Compared With Pegaspargase: A Single Center Retrospective Review.
McCarty Kyra, Smith Caroline, Zhang Song et al. · Pediatr Blood Cancer · 2025
PMID: 40051214Observational
Phase 2 multicenter study of pegaspargase in Japanese patients with previously untreated acute lymphoblastic leukemia.
Koh Katsuyoshi, Kosaka Yoshiyuki, Okamoto Yasuhiro et al. · Int J Hematol · 2025
PMID: 40163215ObservationalFull text (PMC)
Comparison of pegaspargase with concurrent radiation. P-GEMOX with sequential radiation in early-stage NK/T-cell lymphoma.
Feng Demei, Bai Shenrui, Chen Guanjun et al. · Oncol Res · 2025
PMID: 40191721ObservationalFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Pegaspargase (substance)
SNOMED CT
108814000
UMLS CUI
C0071568
RxNorm CUI
34132
Labeler
Servier Pharmaceuticals LLC

Clinical Data

This intervention maps to 3 entities in the Healos knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
2
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.