Substance / Medication

Peginterferon alfa-2a

Overview

Active Ingredient
peginterferon alfa-2a
RxNorm CUI
120608
Labeler: pharmaand GmbHUpdated: 2025-08-11T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

PEGASYS is contraindicated in patients with: PEGASYS is contraindicated in neonates and infants because it contains benzyl alcohol. Benzyl alcohol is associated with an increased incidence of neurologic and other complications which are sometimes fatal in neonates and infants. Warnings and Precautio

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

227 trials linked to this intervention

227
Total Trials
28
Recruiting
76
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Peginterferon alfa-2a (40 kD) stopping rules in chronic hepatitis B: a systematic review and meta-analysis of individual participant data.
Pavlovic Vedran, Yang Lei, Chan Henry Lik-Yuen et al. · Antivir Ther · 2019
PMID: 30865588Meta-Analysis
Effect of peginterferon alfa-2a on liver histology in chronic hepatitis C: a meta-analysis of individual patient data.
Cammà Calogero, Di Bona Danilo, Schepis Filippo et al. · Hepatology · 2004
PMID: 14767986Meta-Analysis
Hepatitis B Surface Antigen Loss with Tenofovir Disoproxil Fumarate Plus Peginterferon Alfa-2a: Week 120 Analysis.
Ahn Sang Hoon, Marcellin Patrick, Ma Xiaoli et al. · Dig Dis Sci · 2018
PMID: 30136045RCTFull text (PMC)
Predictors of response to tenofovir disoproxil fumarate plus peginterferon alfa-2a combination therapy for chronic hepatitis B.
Marcellin P, Ahn S H, Chuang W-L et al. · Aliment Pharmacol Ther · 2016
PMID: 27629859RCT
Long-term effects of peginterferon alfa-2a therapy in Japanese patients with chronic hepatitis B virus infection.
Masaki Keiichi, Suzuki Fumitaka, Hara Tasuku et al. · Virol J · 2015
PMID: 26700861RCTFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Peginterferon alfa-2a (substance)
SNOMED CT
421559001
UMLS CUI
C0391001
RxNorm CUI
120608
Labeler
pharmaand GmbH

Clinical Data

This intervention maps to 26 entities in the Healos knowledge graph.

20
Conditions
3
Biomarkers
2
Specialists
0
Symptoms
227
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.