Substance / Medication

Pemoline

Overview

Active Ingredient
pemoline
RxNorm CUI
7966

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

1
Total Trials
0
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Pemoline (2-amino-5-phenyl-1,3-oxazol-4-one)-induced self-injurious behavior: a rodent model of pharmacotherapeutic efficacy.
Muehlmann Amber M, Brown Brandon D, Devine Darragh P · J Pharmacol Exp Ther · 2008
PMID: 17925479Observational
Self-injurious behaviour: a comparison of caffeine and pemoline models in rats.
Kies Staci D, Devine Darragh P · Pharmacol Biochem Behav · 2004
PMID: 15582667Observational
A rare case of dependence on pemoline.
Bonnet Udo, Davids Eugen · Prog Neuropsychopharmacol Biol Psychiatry · 2006
PMID: 16600453Case Report
Inappropriate pemoline therapy leading to acute liver failure and liver transplantation.
Abbiati C, Vecchi M, Rossi G et al. · Dig Liver Dis · 2002
PMID: 12132793Case Report
Pemoline ingestion in children: a report of five cases and review of the literature.
Nakamura Hidefumi, Blumer Jeffrey L, Reed Michael D · J Clin Pharmacol · 2002
PMID: 11865963Case Report
Severe hypotension in a patient receiving pemoline during general anesthesia.
Bohringer C H, Jahr J S, Rowell S et al. · Anesth Analg · 2000
PMID: 11049895Case Report
Risk Evaluation and Mitigation Strategies (REMS), Pemoline, and What Is a Signal?
Shader Richard I · Clin Ther · 2017
PMID: 28366595Other
The Pemoline Model of Self-Injurious Behavior: An Update.
Devine Darragh P · Methods Mol Biol · 2019
PMID: 31273695Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Pemoline (substance)
SNOMED CT
387393000
UMLS CUI
C0030800
RxNorm CUI
7966

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
1
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.