Substance / Medication

Penciclovir

Overview

Active Ingredient

penciclovir

RxNorm CUI

59839

Indications

Penciclovir cream is a deoxynucleoside analog HSV DNA polymerase inhibitor indicated for the treatment of recurrent herpes labialis (cold sores) in adults and children 12 years of age or older.

Labeler: Torrent Pharmaceuticals LimitedUpdated: 2025-02-04T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Penciclovir cream is contraindicated in patients with known hypersensitivity to the product or any of its components.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Herpes labialis

Herpesvirus infection

Epstein-Barr virus disease

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

A Comparative Study of the Efficacy of Penciclovir 10mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers

NCT00820534Phase 4Completed126 enrolled

View all 1 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Pharmacokinetic modeling of penciclovir and BRL42359 in the plasma and tears of healthy cats to optimize dosage recommendations for oral administration of famciclovir.

Sebbag Lionel, Thomasy Sara M, Woodward Andrew P et al. · Am J Vet Res · 2016

PMID: 27463546RCT

Pharmacokinetics and safety of penciclovir following oral administration of famciclovir to cats.

Thomasy Sara M, Maggs David J, Moulin Nicole K et al. · Am J Vet Res · 2007

PMID: 17975982RCT

Pharmacokinetics of famciclovir and penciclovir in tears following oral administration of famciclovir to cats: a pilot study.

Thomasy Sara M, Covert Jill C, Stanley Scott D et al. · Vet Ophthalmol · 2012

PMID: 22339892Trial

Susceptibility of herpes simplex virus isolates to nucleoside analogues and the proportion of nucleoside-resistant variants after repeated topical application of penciclovir to recurrent herpes labialis.

Shin Young Kyoo, Weinberg Adriana, Spruance Spotswood et al. · J Infect Dis · 2003

PMID: 12696003Trial

Profiling penciclovir susceptibility and prevalence of resistance of herpes simplex virus isolates across eleven clinical trials.

Sarisky R T, Bacon T H, Boon R J et al. · Arch Virol · 2003

PMID: 14505088Trial

Topical application of penciclovir cream for the treatment of herpes simplex facialis/labialis: a randomized, double-blind, multicentre, aciclovir-controlled trial.

Lin L, Chen X S, Cui P G et al. · J Dermatolog Treat · 2002

PMID: 12060504Trial

Effective treatment of herpes simplex labialis with penciclovir cream: combined results of two trials.

Raborn G Wayne, Martel Alain Y, Lassonde Michel et al. · J Am Dent Assoc · 2002

PMID: 11934185Trial

Recurrent herpes labialis: efficacy of topical therapy with penciclovir compared with acyclovir (aciclovir).

Femiano F, Gombos F, Scully C · Oral Dis · 2001

PMID: 11354919Trial

Penciclovir cream for the treatment of sunlight-induced herpes simplex labialis: a randomized, double-blind, placebo-controlled trial. Penciclovir Cream Herpes Labialis Study Group.

Boon R, Goodman J J, Martinez J et al. · Clin Ther · 2000

PMID: 10688392Trial

A comparison of topical application of penciclovir 1% cream with acyclovir 3% cream for treatment of genital herpes: a randomized, double-blind, multicentre trial.

Chen X S, Han G Z, Guo Z P et al. · Int J STD AIDS · 2000

PMID: 10997497Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Penciclovir (substance)
SNOMED CT: 386939003
UMLS CUI: C0164815
RxNorm CUI: 59839
Labeler: Torrent Pharmaceuticals Limited

Clinical Data

This intervention maps to 3 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.