Substance / Medication

Phentolamine

Overview

Active Ingredient
phentolamine
RxNorm CUI
8153

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Effectiveness of phentolamine mesylate, vibration and photobiomodulation in reducing pain and the reversal of local anesthesia: A systematic review.
Olszewska Aneta, Forszt Dominika, Szymczak Aleksandra et al. · Adv Clin Exp Med · 2025
PMID: 39503279Meta-Analysis
EFFECTIVENESS OF PHENTOLAMINE MESYLATE IN REVERSAL OF LOCAL ANESTHESIA: SYSTEMATIC REVIEW AND META-ANALYSIS.
Sardana Divesh, Lee Johyun, Yiu Cynthia Ky et al. · J Evid Based Dent Pract · 2023
PMID: 37689448Meta-Analysis
Safety profile of phentolamine mesylate as reversal agent of pulpal and soft tissue dental anesthesia: a systematic review and meta-analysis.
Vinnakota Dileep Nag, Kamatham Rekhalakshmi · Quintessence Int · 2019
PMID: 31134227Meta-Analysis
Phentolamine mesylate to reverse oral soft-tissue local anesthesia: A systematic review and meta-analysis.
Prados-Frutos Juan Carlos, Rojo Rosa, González-Serrano José et al. · J Am Dent Assoc · 2015
PMID: 26409985Meta-Analysis
Reversal of Pharmacologically Induced Mydriasis with Phentolamine Ophthalmic Solution.
Pepose Jay S, Wirta David, Evans David et al. · Ophthalmology · 2025
PMID: 39293681RCT
Phentolamine and B vitamins for feeding intolerance in late preterm infants: a randomised trial.
Lv Yuan-Yuan, Gao Ning, He Xin et al. · Asia Pac J Clin Nutr · 2024
PMID: 38794979RCTFull text (PMC)
Inferior alveolar nerve block anesthesia in children: The effect of ibuprofen and phentolamine mesylate on pain perception.
Nayak Ullal Anand, Ramasamy Saravanan, Marusamy Kavitha Odathurai et al. · J Indian Soc Pedod Prev Dent · 2024
PMID: 38957911RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Phentolamine (substance)
SNOMED CT
372863003
UMLS CUI
C0031448
RxNorm CUI
8153

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.