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Substance / Medication

Piperazine

SNOMED 428714003UMLS C0031957

Overview

Active Ingredient
piperazine
RxNorm CUI
8340

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Ascariasis
Nematode infection
Infection by Enterobius vermicularis

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

1
Total Trials
0
Recruiting
0
With Results

Recent Trials

Impact of Alternative Treatment Strategies and Delivery Systems for Soil-transmitted Helminths in Kenya

NCT02397772Phase 4Completed21761 enrolled
View all 1 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:
Improving renoprotective effects by adding piperazine ferulate and angiotensin receptor blocker in diabetic nephropathy: a meta-analysis of randomized controlled trials.
Yang Chiehlun, Yang Wenhsing, Chen Yenjen et al. · Int Urol Nephrol · 2022
PMID: 34191230Meta-Analysis
Meta-Chlorophenylpiperazine-Induced Behavioral Changes in Obsessive-Compulsive Disorder Research: A Systematic Review of Rodent Studies.
da Silva Jéssica Fernandes, Taguchi Leticia Mitsuko, Leite Erinete da Silva et al. · Neuroscience · 2022
PMID: 36332691Meta-Analysis
Therapeutic Efficacy of Piperazine Ferulate Combined With Irbesartan in Diabetic Nephropathy: A Systematic Review and Meta-analysis.
Li Dan, Li Bo, Peng Li-Xia et al. · Clin Ther · 2020
PMID: 33158581Meta-Analysis
The 5-HTreceptor agonist meta-chlorophenylpiperazine (mCPP) reduces palatable food consumption and BOLD fMRI responses to food images in healthy female volunteers.
Thomas Jason M, Dourish Colin T, Tomlinson Jeremy et al. · Psychopharmacology (Berl) · 2018
PMID: 29080906RCTFull text (PMC)
Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m-chlorophenylpiperazine in the horse.
Davis J L, Schirmer J, Medlin E · J Vet Pharmacol Ther · 2018
PMID: 29333613RCTFull text (PMC)
Investigation of the effects of 'piperazine-containing party pills' and dexamphetamine on interhemispheric communication using electroencephalography.
Lee HeeSeung, Wang Grace Y, Curley Louise E et al. · Psychopharmacology (Berl) · 2016
PMID: 27289365RCT
Using fMRI to compare the effects of benzylpiperazine with dexamphetamine - Their differences during the Stroop paradigm.
Curley Louise E, Kydd Robert R, Kirk Ian J et al. · J Integr Neurosci · 2016
PMID: 26912213RCT
Pharmacokinetic evaluation of a newly developed piperazine dithioctate formulation in healthy volunteers.
Zheng Renhua, Song Hyung Ho, Kwon Young Ee et al. · Int J Clin Pharmacol Ther · 2014
PMID: 25345429RCT
Effects of the 5-HT2C receptor agonist meta-chlorophenylpiperazine on appetite, food intake and emotional processing in healthy volunteers.
Thomas J M, Dourish C T, Tomlinson J W et al. · Psychopharmacology (Berl) · 2014
PMID: 24408211RCT
A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel Imidazolopiperazine KAF156 to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers.
Leong F Joel, Zhao Rong, Zeng Shuqi et al. · Antimicrob Agents Chemother · 2014
PMID: 25136017RCTFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Piperazine (substance)
SNOMED CT
428714003
UMLS CUI
C0031957
RxNorm CUI
8340

Clinical Data

This intervention maps to 3 entities in the Healos knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
1
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.