No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Optimising TREATment for Severe Gram-Negative Bacterial Infections

NCT07004049Phase 4Recruiting600 enrolled

View all 1 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

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A Systematic Review of Pharmacokinetic Studies of Colistin and Polymyxin B in Adult Populations.

Zamri Puteri Juanita, Lim Sazlyna Mohd Sazlly, Sime Fekade Bruck et al. · Clin Pharmacokinet · 2025

PMID: 40246790Meta-AnalysisFull text (PMC)

Pharmacokinetics of polymyxin B in different populations: a systematic review.

Wang Xing, Xiong Wenqiang, Zhong Maolian et al. · Eur J Clin Pharmacol · 2024

PMID: 38483544Meta-Analysis

Factors affecting the effectiveness and safety of polymyxin B in the treatment of Gram-negative bacterial infections: A meta-analysis of 96 articles.

Zhao Yi-Chang, Wang Chen-Yu, Liu Jia-Yi et al. · Int J Antimicrob Agents · 2024

PMID: 38945178Meta-Analysis

Effectiveness and Safety of Compound Polymyxin B Ointment in Treatment of Burn Wounds: A Meta-analysis.

Lu Li-Chin, Chang Fei-Yu, Lv Guo-Zhong et al. · J Burn Care Res · 2022

PMID: 34091661Meta-Analysis

Clinical use of intravenous polymyxin B for the treatment of patients with multidrug-resistant Gram-negative bacterial infections: An evaluation of the current evidence.

Falagas Matthew E, Kyriakidou Margarita, Voulgaris Georgios L et al. · J Glob Antimicrob Resist · 2021

PMID: 33486122Meta-Analysis

Effectiveness of polymyxin B-immobilized hemoperfusion against sepsis and septic shock: A systematic review and meta-analysis.

Li Xiaoming, Liu Chao, Mao Zhi et al. · J Crit Care · 2021

PMID: 33012579Meta-Analysis

Polymyxin B-immobilized hemoperfusion and mortality in critically ill adult patients with sepsis/septic shock: a systematic review with meta-analysis and trial sequential analysis.

Fujii Tomoko, Ganeko Riki, Kataoka Yuki et al. · Intensive Care Med · 2018

PMID: 29204670Meta-Analysis

Personalizing Polymyxin B Dosing Using an Adaptive Feedback Control Algorithm.

Lakota Elizabeth A, Landersdorfer Cornelia B, Nation Roger L et al. · Antimicrob Agents Chemother · 2018

PMID: 29760144Meta-AnalysisFull text (PMC)

Polymyxin B Hemoperfusion for Sepsis and Septic Shock: A Systematic Review and Meta-Analysis.

Terayama Takero, Yamakawa Kazuma, Umemura Yutaka et al. · Surg Infect (Larchmt) · 2017

PMID: 28092497Meta-Analysis

Effects of Polymyxin B Hemoperfusion on Mortality in Patients With Severe Sepsis and Septic Shock: A Systemic Review, Meta-Analysis Update, and Disease Severity Subgroup Meta-Analysis.

Chang Tzu, Tu Yu-Kang, Lee Chen-Tse et al. · Crit Care Med · 2017

PMID: 28445237Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Polymyxin B (substance)
SNOMED CT: 372824005
UMLS CUI: C0032535
RxNorm CUI: 8536

Clinical Data

This intervention maps to 13 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.