Substance / Medication

Potassium bicarbonate

Overview

Active Ingredient
potassium bicarbonate
RxNorm CUI
34296

Indications

For therapeutic use in patients with hypokalemia with or without metabolic alkalosis; in chronic digitalis intoxication; and in patients with hypokalemic familial periodic paralysis. For prevention of potassium depletion when the dietary intake of potassium ion is inadequate in the following conditions; patients receiving digitalis and diuretics for congestive heart failure; hepatic cirrhosis with ascites; states of aldosterone excess with normal renal function; potassiumlosing nephropathy, and

Labeler: Nomax Inc.Updated: 2019-12-23T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Potassium supplements are contraindicated in patients with hyperkalemia since a further increase in serum potassium concentration in such patients can produce cardiac arrest. Conditions predisposing to hyperkalemia include: chronic renal failure, acute metabolic acidosis, uncontrolled diabetes melli

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Research Evidence

Published studies and systematic reviews

Sort:
Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days of bed rest.
Bosutti Alessandra, Salanova Michele, Blottner Dieter et al. · J Appl Physiol (1985) · 2016
PMID: 27516541RCT
Potassium Bicarbonate Supplementation Lowers Bone Turnover and Calcium Excretion in Older Men and Women: A Randomized Dose-Finding Trial.
Dawson-Hughes Bess, Harris Susan S, Palermo Nancy J et al. · J Bone Miner Res · 2015
PMID: 25990255RCTFull text (PMC)
Treatment with potassium bicarbonate lowers calcium excretion and bone resorption in older men and women.
Dawson-Hughes Bess, Harris Susan S, Palermo Nancy J et al. · J Clin Endocrinol Metab · 2009
PMID: 18940881RCTFull text (PMC)
Effects of potassium chloride and potassium bicarbonate in the diet on urinary pH and mineral excretion of adult cats.
Passlack Nadine, Brenten Thomas, Neumann Konrad et al. · Br J Nutr · 2014
PMID: 24229496Observational
The importance of potassium citrate and potassium bicarbonate in the treatment of uric acid renal stones.
Barbera Michele, Tsirgiotis Andreas, Barbera Mauro et al. · Arch Ital Urol Androl · 2016
PMID: 28073209Case Report
Potassium bicarbonate, not sodium bicarbonate, maintains acidosis-mediated bone dissolution.
Moody Mikayla, Zainadine Nayara, Doktorski Trey et al. · Bone · 2025
PMID: 39674389Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Potassium bicarbonate (substance)
SNOMED CT
77849004
UMLS CUI
C0071751
RxNorm CUI
34296
Labeler
Nomax Inc.

Clinical Data

This intervention maps to 7 entities in the Healos knowledge graph.

1
Conditions
3
Biomarkers
2
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.