Substance / Medication

Protamine sulfate

Overview

Active Ingredient
protamine sulfate (USP)
RxNorm CUI
8825

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Serious anaphylactic reactions due to protamine sulfate: a systematic literature review.
Nybo Mads, Madsen Jonna Skov · Basic Clin Pharmacol Toxicol · 2008
PMID: 18816305Meta-Analysis
Protamine sulfate during transcatheter aortic valve implantation (PS TAVI) - a single-center, single-blind, randomized placebo-controlled trial.
Zbroński Karol, Grodecki Kajetan, Gozdowska Roksana et al. · Kardiol Pol · 2021
PMID: 34292562RCT
Heparin reversal with protamine sulfate is not required in atrial fibrillation ablation with suture hemostasis.
Yasar Senan J, Bickel Trent, Zhang Shiyang et al. · J Cardiovasc Electrophysiol · 2019
PMID: 31661173Observational
New synthetic peptide with efficacy for heparin reversal and low toxicity and immunogenicity in comparison to protamine sulfate.
Li Tong, Meng Zhiyun, Zhu Xiaoxia et al. · Biochem Biophys Res Commun · 2015
PMID: 26456655Observational
In vivo leukocyte labeling with intravenous ferumoxides/protamine sulfate complex and in vitro characterization for cellular magnetic resonance imaging.
Wu Y Jeffrey, Muldoon Leslie L, Varallyay Csanad et al. · Am J Physiol Cell Physiol · 2007
PMID: 17898131Observational
Anaphylactic Reaction to Protamine Sulfate: A Case Report.
David do Carmo Ana, Nascimento Margarida L, Carvalho Inês R et al. · Cureus · 2024
PMID: 39421103Case ReportFull text (PMC)
Reversal of life-threatening bleeding with protamine sulfate in a patient with plasma cell leukemia.
VanDommelen Kyle, Omer Zulfa, Hambley Bryan C et al. · Blood Coagul Fibrinolysis · 2022
PMID: 35946464Case Report
A reversal of fortune: A case of cardiovascular collapse following protamine sulfate infusion.
Geurink Kyle R, Granger Christopher B, Liao Lawrence et al. · HeartRhythm Case Rep · 2020
PMID: 32577386Case ReportFull text (PMC)
Kounis Syndrome Induced by Protamine Sulfate.
Amro Mohammad, Mansoor Kanaan, Amro Ahmed et al. · Cureus · 2020
PMID: 32190518Case ReportFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Protamine sulfate (substance)
SNOMED CT
64520006
UMLS CUI
C0033602
RxNorm CUI
8825

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.