Substance / Medication

Protriptyline

Overview

Active Ingredient
protriptyline
RxNorm CUI
8886

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

48 trials linked to this intervention

48
Total Trials
5
Recruiting
17
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Effect of protriptyline on [Ca]and viability in MG63 human osteosarcoma cells.
Su Ching-Kai, Chou Chiang-Ting, Lin Ko-Long et al. · Toxicol Mech Methods · 2016
PMID: 27790936Other
CaSignaling and Cell Death Induced by Protriptyline in HepG2 Human Hepatoma Cells.
Wang Jue-Long, Chou Chiang-Ting, Liu Kang et al. · J Biochem Mol Toxicol · 2016
PMID: 27252039Other
The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells.
Chang Hong-Tai, Chou Chiang-Ting, Yu Chia-Cheng et al. · J Recept Signal Transduct Res · 2015
PMID: 26096164Other
Protriptyline, a tricyclic antidepressant, inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells.
An Jin Ryeol, Kang Hojung, Li Hongliang et al. · Acta Biochim Biophys Sin (Shanghai) · 2020
PMID: 32060505Preclinical
Effect of Protriptyline on [Ca²⁺]i and Viability in MDCK Renal Tubular Cells.
Cheng He-Hsiung, Chou Chiang-Ting, Liang Wei-Zhe et al. · Chin J Physiol · 2017
PMID: 28468029Preclinical
Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease.
Bansode Sneha B, Jana Asis K, Batkulwar Kedar B et al. · PLoS One · 2014
PMID: 25141174PreclinicalFull text (PMC)
Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel.
Jo Su-Hyun, Hong Hee-Kyung, Chong Seon Ha et al. · Life Sci · 2008
PMID: 18191158Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Protriptyline (substance)
SNOMED CT
372760009
UMLS CUI
C0033743
RxNorm CUI
8886

Clinical Data

This intervention maps to 8 entities in the Healos knowledge graph.

2
Conditions
3
Biomarkers
2
Specialists
0
Symptoms
48
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.