Substance / Medication

Quinapril

Overview

Active Ingredient
quinapril
RxNorm CUI
35208
Labeler: Carilion Materials ManagementUpdated: 2014-06-13T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

When pregnancy is detected, discontinue quinapril hydrochloride tablets as soon as possible. Warnings: Fetal Toxicity Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See

Contraindications

When this intervention should not be used

Quinapril hydrochloride tablets are contraindicated in patients who are hypersensitive to this product and in patients with a history of angioedema related to previous treatment with an ACE inhibitor. Do not co-administer quinapril hydrochloride tablets with aliskiren in patients with diabetes.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Research Evidence

Published studies and systematic reviews

Sort:
Pharmacokinetics and bioequivalence study of the two 20-mg quinapril hydrochloride tablet formulations in healthy Thai male volunteers.
Rojanasthien Noppamas, Nasangiam Nayada, Kumsorn Boonyium et al. · J Med Assoc Thai · 2008
PMID: 18672641RCT
Haemodynamic effects of intravenous quinaprilat in comparison to sodium nitroprusside in patients with chronic heart failure.
Kieback Arne G, Grohmann Andrea, Baumann Gert et al. · Int J Cardiol · 2007
PMID: 17098309RCT
The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction.
Bank Alan J, Kelly Aaron S, Kaiser Daniel R et al. · Vasc Med · 2006
PMID: 17390549RCT
Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes.
Hermann Thomas S, Li Weijie, Dominguez Helena et al. · J Clin Endocrinol Metab · 2006
PMID: 16352688RCT
Statins, fenofibrate, and quinapril increase clot permeability and enhance fibrinolysis in patients with coronary artery disease.
Undas A, Celinska-Löwenhoff M, Löwenhoff T et al. · J Thromb Haemost · 2006
PMID: 16689755RCT
Effects of quinapril on left atrial structural remodeling and arterial stiffness.
Tsang Teresa S M, Barnes Marion E, Abhayaratna Walter P et al. · Am J Cardiol · 2006
PMID: 16516602RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Quinapril (substance)
SNOMED CT
386874003
UMLS CUI
C0072857
RxNorm CUI
35208
Labeler
Carilion Materials Management

Clinical Data

This intervention maps to 10 entities in the Healos knowledge graph.

3
Conditions
4
Biomarkers
2
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.