Substance / Medication

Rifampin

Overview

Active Ingredient
rifampin
RxNorm CUI
9384

Indications

In the treatment of both tuberculosis and the meningococcal carrier state, the small number of resistant cells present within large populations of susceptible cells can rapidly become the predominant type. Bacteriologic cultures should be obtained before the start of therapy to confirm the susceptibility of the organism to rifampin and they should be repeated throughout therapy to monitor the response to treatment. Since resistance can emerge rapidly, susceptibility tests should be performed in

Labeler: Lupin Pharmaceuticals, Inc.Updated: 2026-02-11T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

WARNINGS Rifampin capsules are contraindicated in patients with a history of hypersensitivity to rifampin or any of the components, or to any of the rifamycins. (See). PRECAUTIONS, Drug Interactions Rifampin is contraindicated in patients who are also receiving ritonavir-boosted saquinavir due to an

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaLM) for multidrug- or rifampin-resistant tuberculosis: a systematic review.
Silva Denise Rossato, Fernandes Flávia Fonseca, Ferreira Juliana Carvalho et al. · J Bras Pneumol · 2025
PMID: 39813501Meta-AnalysisFull text (PMC)
Representativeness and adverse event reporting in late-phase clinical trials for rifampin-susceptible tuberculosis: a systematic review.
Burman William, Luczynski Pauline, Horsburgh C Robert et al. · Lancet Infect Dis · 2025
PMID: 39612926Meta-Analysis
Safety of Triple-Dose Rifampin in Tuberculosis Treatment: A Systematic Review and Meta-Analysis.
Arbiv Omri A, Holmes Thomas, Kim Marie JeongMin et al. · Clin Infect Dis · 2025
PMID: 39789804Meta-AnalysisFull text (PMC)
Rifampin Based Therapy for Patients With Staphylococcus aureus Native Vertebral Osteomyelitis: A Systematic Review and Meta-analysis.
El Zein Said, Berbari Elie F, Passerini Matteo et al. · Clin Infect Dis · 2024
PMID: 37721158Meta-AnalysisFull text (PMC)
Unravelling the challenge of cotrimoxazole and rifampin resistance in B. melitensis and B. abortus: A systematic review and meta-analysis.
Beig Masoumeh, Ebrahimi Elaheh, Moradkasani Safoura et al. · PLoS Negl Trop Dis · 2024
PMID: 39621798Meta-AnalysisFull text (PMC)
Association of indicators of extensive disease and rifampin-resistant tuberculosis treatment outcomes: an individual participant data meta-analysis.
Campbell Jonathon R, Brode Sarah K, Barry Pennan et al. · Thorax · 2024
PMID: 38135489Meta-Analysis
The Use of Rifampin in Total Joint Arthroplasty: A Systematic Review and Meta-Analysis of Comparative Studies.
Kruse Colin C, Ekhtiari Seper, Oral Ismet et al. · J Arthroplasty · 2022
PMID: 35346810Meta-Analysis
Rifampin-accompanied antibiotic regimens in the treatment of prosthetic joint infections: a frequentist and Bayesian meta-analysis of current evidence.
Aydın Ozlem, Ergen Pinar, Ozturan Burak et al. · Eur J Clin Microbiol Infect Dis · 2021
PMID: 33125602Meta-Analysis
Adjunctive rifampin for the treatment of Staphylococcus aureus bacteremia with deep infections: A meta-analysis.
Ma Huan, Cheng Jie, Peng Lengyue et al. · PLoS One · 2020
PMID: 32191760Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Rifampicin (substance)
SNOMED CT
387159009
UMLS CUI
C0035608
RxNorm CUI
9384
Labeler
Lupin Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 10 entities in the Healos knowledge graph.

10
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.