Substance / Medication

Ritonavir

Overview

Active Ingredient
ritonavir
RxNorm CUI
85762

Indications

Ritonavir tablets are indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.

Labeler: NuCare Pharmaceuticals, Inc.Updated: 2025-09-24T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

[see Contraindications (4) , Warnings and Precautions (5.1) ]. Co-administration of ritonavir with several classes of drugs including sedative hypnotics, antiarrhythmics, or ergot alkaloid preparations may result in potentially serious and/or life-threatening adverse events due to possible effects o

Contraindications

When this intervention should not be used

When co-administering ritonavir tablets with other protease inhibitors, see the full prescribing information for that protease inhibitor including contraindication information. Ritonavir tablets are contraindicated in patients with known hypersensitivity (e.g., toxic epidermal necrolysis (TEN) or St

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

67 trials linked to this intervention

67
Total Trials
4
Recruiting
24
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Nirmatrelvir/ritonavir treatment for COVID-19: an economic value systematic literature review.
Mugwagwa Tendai, Marcano Belisario José, Hartley Louise et al. · J Med Econ · 2025
PMID: 41134222Meta-Analysis
Evaluating the safety and efficacy of nirmatrelvir-ritonavir therapy in pregnant women with COVID-19: a systematic review and meta-analysis.
Hassan Omar, Elbhairy Aya Abdulkarim, Siam Aya Magdy et al. · Eur J Clin Pharmacol · 2025
PMID: 39948217Meta-Analysis
Effectiveness of nirmatrelvir/ritonavir and molnupiravir in non-hospitalized adults with COVID-19: systematic review and meta-analysis of observational studies.
Mesfin Yonatan M, Blais Joseph E, Kibret Kelemu Tilahun et al. · J Antimicrob Chemother · 2024
PMID: 38817046Meta-AnalysisFull text (PMC)
Effectiveness of nirmatrelvir-ritonavir on severe outcomes of COVID-19 in the era of vaccination and Omicron: An updated meta-analysis.
Ombelet Sien, Castanares-Zapatero Diego, Desimpel Fabian et al. · J Med Virol · 2024
PMID: 38376947Meta-Analysis
Comparison of effectiveness and safety of nirmatrelvir/ritonavir versus sotrovimab for COVID-19: a systematic review and meta-analysis.
Amani Behnam, Amani Bahman · Expert Rev Anti Infect Ther · 2024
PMID: 38457124Meta-Analysis
Nirmatrelvir/ritonavir for COVID-19: an overview of systematic reviews.
Cruciani Mario, Pati Ilaria, Masiello Francesca et al. · J Antimicrob Chemother · 2024
PMID: 38084876Meta-Analysis
Efficacy and safety of paxlovid (nirmatrelvir/ritonavir) in the treatment of COVID-19: An updated meta-analysis and trial sequential analysis.
Tian Haokun, Yang Changsen, Song Tiangang et al. · Rev Med Virol · 2023
PMID: 37485774Meta-Analysis
Comparative efficacy and safety of nirmatrelvir/ritonavir and molnupiravir for COVID-19: A systematic review and meta-analysis.
Amani Bahman, Akbarzadeh Arash, Amani Behnam et al. · J Med Virol · 2023
PMID: 37368841Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Ritonavir (substance)
SNOMED CT
386896009
UMLS CUI
C0292818
RxNorm CUI
85762
Labeler
NuCare Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
67
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.