Substance / Medication

Satralizumab

Overview

Active Ingredient
satralizumab
RxNorm CUI
2391541

Indications

ENSPRYNG is indicated for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive.

Labeler: Genentech, Inc.Updated: 2025-12-03T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

ENSPRYNG is contraindicated in patients with: Warnings and Precautions (5.4) [see] A known hypersensitivity to satralizumab or any of the inactive ingredients Warnings and Precautions (5.1) [see] Active Hepatitis B infection Warnings and Precautions (5.1) [see] Active or untreated latent tuberculosi

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Long-term Efficacy of Satralizumab in AQP4-IgG-Seropositive Neuromyelitis Optica Spectrum Disorder From SAkuraSky and SAkuraStar.
Kleiter Ingo, Traboulsee Anthony, Palace Jacqueline et al. · Neurol Neuroimmunol Neuroinflamm · 2023
PMID: 36724181RCTFull text (PMC)
Long-Term Efficacy and Safety of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disorder From the SAkuraMoon Open-Label Extension Study.
Bennett Jeffrey L, Fujihara Kazuo, Saiz Albert et al. · Neurol Neuroimmunol Neuroinflamm · 2025
PMID: 40743487TrialFull text (PMC)
Analysis of infection rates in neuromyelitis optica spectrum disorder: Comparing satralizumab treatment in SAkuraMoon, post-marketing, and US-based health claims data.
Greenberg Benjamin M, Fujihara Kazuo, Weinshenker Brian et al. · Mult Scler Relat Disord · 2025
PMID: 40288333Trial
Exploring steroid tapering in patients with neuromyelitis optica spectrum disorder treated with satralizumab in SAkuraSky: A case series.
Yamamura Takashi, Araki Manabu, Fujihara Kazuo et al. · Mult Scler Relat Disord · 2022
PMID: 35537314Trial
Long-term safety of satralizumab in neuromyelitis optica spectrum disorder (NMOSD) from SAkuraSky and SAkuraStar.
Yamamura Takashi, Weinshenker Brian, Yeaman Michael R et al. · Mult Scler Relat Disord · 2022
PMID: 36007339Trial
Trial of Satralizumab in Neuromyelitis Optica Spectrum Disorder.
Yamamura Takashi, Kleiter Ingo, Fujihara Kazuo et al. · N Engl J Med · 2019
PMID: 31774956Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Satralizumab (substance)
SNOMED CT
897234001
UMLS CUI
C4726732
RxNorm CUI
2391541
Labeler
Genentech, Inc.

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.

Satralizumab: Uses, Evidence & Side Effects | Ltrl