Substance / Medication

Selexipag

Overview

Active Ingredient
selexipag
RxNorm CUI
1729002
Labeler: Zydus Lifesciences LimitedUpdated: 2025-11-07T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Hypersensitivity to the active substance or to any of the excipients. 7.1 12.3 [see Drug Interactions () and Clinical Pharmacology ()]. Concomitant use of strong inhibitors of CYP2C8 (e.g., gemfibrozil)

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

55 trials linked to this intervention

55
Total Trials
13
Recruiting
16
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Selexipag for the Treatment of Pediatric Pulmonary Hypertension: A Systematic Review.
Li Meng, Liu Lin, Liu Cong et al. · Clin Ther · 2024
PMID: 37945502Meta-Analysis
Selexipag in Patients With Pulmonary Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Qin Jinlv, Wang Guizuo, Han Dong · Curr Probl Cardiol · 2023
PMID: 36283497Meta-Analysis
Efficacy and safety of selexipag, an oral prostacyclin receptor agonist for the treatment of pulmonary hypertension: A meta-analysis.
Chen Minshan, Lai Yuanqiang, Chen Riken et al. · Pulm Pharmacol Ther · 2022
PMID: 34856365Meta-Analysis
Indirect treatment comparison and cost-minimization analysis of riociguat versus selexipag in patients with pulmonary arterial hypertension.
Ornstová Eva, Tužil Jan, Chadimová Kateřina et al. · Expert Rev Pharmacoecon Outcomes Res · 2022
PMID: 36121156Meta-Analysis
Selexipag, an Oral Prostacyclin-Receptor Agonist for Pulmonary Arterial Hypertension.
Baker William L, Darsaklis Konstadina, Singhvi Aditi et al. · Ann Pharmacother · 2017
PMID: 28478717Meta-Analysis
Population pharmacokinetics of selexipag for dose selection and confirmation in pediatric patients with pulmonary arterial hypertension.
Axelsen Lene Nygaard, Kümmel Anne, Perez Ruixo Juan Jose et al. · CPT Pharmacometrics Syst Pharmacol · 2024
PMID: 39570749RCTFull text (PMC)
Efficacy and safety of selexipag in patients with inoperable or persistent/recurrent CTEPH (SELECT randomised trial).
Kim Nick H, Channick Richard, Delcroix Marion et al. · Eur Respir J · 2024
PMID: 39326918RCTFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Selexipag (substance)
SNOMED CT
717359004
UMLS CUI
C2000145
RxNorm CUI
1729002
Labeler
Zydus Lifesciences Limited

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
55
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.