Substance / Medication

Silybum marianum extract

Overview

Active Ingredient
milk thistle extract
RxNorm CUI
283579

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

8 trials linked to this intervention

8
Total Trials
1
Recruiting
4
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Impact of COVID-19 in patients with concurrent co-infections: A systematic review and meta-analyses.
Sarkar Soumya, Khanna Puneet, Singh Akhil Kant · J Med Virol · 2021
PMID: 33331656Meta-Analysis
Hepatitis E virus infection in Turkey: a systematic review.
Leblebicioglu Hakan, Ozaras Resat · Ann Clin Microbiol Antimicrob · 2018
PMID: 29716597Meta-AnalysisFull text (PMC)
Risk of colorectal cancer in chronic liver diseases: a systematic review and meta-analysis.
Komaki Yuga, Komaki Fukiko, Micic Dejan et al. · Gastrointest Endosc · 2017
PMID: 28011280Meta-Analysis
Prevalence of non-HIV cancer risk factors in persons living with HIV/AIDS: a meta-analysis.
Park Lesley S, Hernández-Ramírez Raúl U, Silverberg Michael J et al. · AIDS · 2016
PMID: 26691548Meta-AnalysisFull text (PMC)
Impact of coffee on liver diseases: a systematic review.
Saab Sammy, Mallam Divya, Cox Gerald A et al. · Liver Int · 2014
PMID: 24102757Meta-Analysis
[A meta-analysis of diammonium glycyrrhizinate enteric-coated capsules versus diammonium glycyrrihizinate in patients with chronic viral hepatitis].
Ling Qingxia, Jin Honghui, Zheng Jianming et al. · Zhonghua Gan Zang Bing Za Zhi · 2014
PMID: 25203702Meta-Analysis
Occult hepatitis B virus and the risk for chronic liver disease: a meta-analysis.
Covolo Loredana, Pollicino Teresa, Raimondo Giovanni et al. · Dig Liver Dis · 2013
PMID: 23146778Meta-Analysis
Pediatric celiac disease, cryptogenic hypertransaminasemia, and autoimmune hepatitis.
Vajro Pietro, Paolella Giulia, Maggiore Giuseppe et al. · J Pediatr Gastroenterol Nutr · 2013
PMID: 23434875Meta-Analysis
Evaluation of the effect of Silybum marianum extract on menopausal symptoms: A randomized, double-blind placebo-controlled trial.
Saberi Zohreh, Gorji Narjes, Memariani Zahra et al. · Phytother Res · 2020
PMID: 32762030RCT
Silybum marianum Extract: A Highly Effective Natural Alternative to Retinoids to Prevent Skin Aging Without Side Effects.
Boira Cloe, Chapuis Emilie, Lapierre Laura et al. · J Cosmet Dermatol · 2025
PMID: 39692756TrialFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Silybum marianum extract (substance)
SNOMED CT
412434008
UMLS CUI
C0937640
RxNorm CUI
283579

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
8
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.