Substance / Medication

Sodium fluoride

Overview

Active Ingredient
sodium fluoride
RxNorm CUI
9873

Indications

1-4 WARNINGS A dental caries preventive; for once daily self-applied topical use. It is well established that 1.1% sodium fluoride is safe and extraordinarily effective as a caries preventive when applied frequently with mouthpiece applicators.Sodium Fluoride 1.1% Dental Gel in a squeeze-tube is easily applied onto a toothbrush. This prescription dental gel should be used once daily following use of your regular toothpaste unless otherwise instructed by your dental professional. May be used whet

Labeler: Burel Pharmaceuticals LLCUpdated: 2025-11-14T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Do not use in pediatric patients under age 6 years unless recommended by a dentist or physician.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Research Evidence

Published studies and systematic reviews

Sort:
Antioxidants against oxidative stress induced by sodium fluoride toxicity in murine models: A systematic review.
Ortiz-Barroso Gladys, Ramírez-Orozco Ricardo E, Esparza-Villalpando Vicente et al. · J Trace Elem Med Biol · 2025
PMID: 40020477Meta-Analysis
Sodium fluoride in cardiovascular disorders: A systematic review.
Silva Mendes Beatriz Isabel, Oliveira-Santos Manuel, Vidigal Ferreira Maria João · J Nucl Cardiol · 2021
PMID: 31388965Meta-Analysis
Limited evidence for the effect of sodium fluoride on deterioration of hearing loss in patients with otosclerosis: a systematic review of the literature.
Hentschel Mayke A, Huizinga Pepijn, van der Velden Daphne L et al. · Otol Neurotol · 2014
PMID: 24751746Meta-Analysis
Caries-preventive effect of sodium fluoride mouthrinses: a systematic review of controlled clinical trials.
Twetman Svante, Petersson Lars, Axelsson Susanna et al. · Acta Odontol Scand · 2004
PMID: 15513419Meta-Analysis
Reduction in dental caries with four concentrations of sodium fluoride in a dentifrice: a meta-analysis evaluation.
Bartizek R D, Gerlach R W, Faller R V et al. · J Clin Dent · 2001
PMID: 11505961Meta-Analysis
Plaque and Salivary Fluoride Levels in Preschoolers Following Applications of Silver Diamine Fluoride, Sodium Fluoride Varnish, and Their Combination: A Randomized Clinical Trial.
Asavalertpalakorn Chavanya, Jirarattanasopha Varangkanar, Nakornchai Siriruk et al. · Int J Paediatr Dent · 2026
PMID: 40898598RCTFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Sodium fluoride (substance)
SNOMED CT
6910009
UMLS CUI
C0037508
RxNorm CUI
9873
Labeler
Burel Pharmaceuticals LLC

Clinical Data

This intervention maps to 7 entities in the Healos knowledge graph.

1
Conditions
2
Biomarkers
2
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.