Substance / Medication

Sodium lactate

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Acidosis

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

7 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Arterial pH and Total Body Nitrogen Balances in APD

NCT00586131Phase 4Completed8 enrolled

Alkalinization by Urologists & Nephrologists

NCT03035812Phase 4Completed156 enrolled

Preserve-Transplant Study

NCT03102996Phase 4Completed240 enrolled

Optimal Dosage of Acetazolamide for OSA Treatment

NCT04726982Phase 4Completed91 enrolled

Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients

NCT05005793Phase 4Recruiting120 enrolled

View all 7 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Comparison of Sodium Lactate Infusion and Carbon Dioxide Inhalation Panic Provocation Tests: A Meta-analysis.

Tural Umit, Iosifescu Dan V · Pharmacopsychiatry · 2022

PMID: 34666404Meta-Analysis

Comparison of half-molar sodium lactate and mannitol to treat brain edema in severe traumatic brain injury: A systematic review.

Bajamal Abdul Hafid, Apriawan Tedy, Ranuh I G M Aswin R et al. · Chin J Traumatol · 2021

PMID: 34344615Meta-AnalysisFull text (PMC)

Intraoperative Use of Sodium Bicarbonate Ringer's Solution Instead of Sodium Lactate Ringer's Solution to Reduce Endothelial Glycocalyx Degradation and Improve Postoperative Recovery During Cardiopulmonary Bypass Cardiac Surgery: A Single-Center Prospective Cohort Study.

Shi Yujie, Shi Yuan, Tao Yujia et al. · Drug Des Devel Ther · 2024

PMID: 39679133RCTFull text (PMC)

Comparison of fluid balance and hemodynamic and metabolic effects of sodium lactate versus sodium bicarbonate versus 0.9% NaCl in porcine endotoxic shock: a randomized, open-label, controlled study.

Duburcq Thibault, Durand Arthur, Dessein Anne-Frédérique et al. · Crit Care · 2017

PMID: 28526086RCTFull text (PMC)

Half-molar sodium lactate infusion improves cardiac performance in acute heart failure: a pilot randomised controlled clinical trial.

Nalos Marek, Leverve Xavier, Huang Stephen et al. · Crit Care · 2014

PMID: 24666826RCTFull text (PMC)

Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trial.

Ichai Carole, Payen Jean-François, Orban Jean-Christophe et al. · Intensive Care Med · 2013

PMID: 23749153RCT

Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients.

Ichai Carole, Armando Guy, Orban Jean-Christophe et al. · Intensive Care Med · 2009

PMID: 18807008RCT

[The use of composite sodium lactate and sorbitol composition in fluid resuscitation for shock in patients with major burn].

Zeng Ji-zhang, Huang Xiao-yuan, Yang Xing-hua et al. · Zhonghua Shao Shang Za Zhi · 2005

PMID: 16383032RCT

The comparative effects of 3% saline and 0.5M sodium lactate on cardiac function:a randomised, crossover study in volunteers.

Nalos Marek, Kholodniak Euguenia, Smith Louise et al. · Crit Care Resusc · 2018

PMID: 29852851Observational

Comparative transcriptome analysis reveals different molecular mechanisms of Bacillus coagulans 2-6 response to sodium lactate and calcium lactate during lactic acid production.

Qin Jiayang, Wang Xiuwen, Wang Landong et al. · PLoS One · 2015

PMID: 25875592ObservationalFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Sodium lactate (substance)
SNOMED CT: 387306001
UMLS CUI: C0142874

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.