Substance / Medication

Tenecteplase

Overview

Active Ingredient
tenecteplase
RxNorm CUI
259280

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

7 trials linked to this intervention

7
Total Trials
4
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Tenecteplase for Acute Ischemic Stroke at 4.5 to 24 Hours: A Meta-Analysis of Randomized Controlled Trials.
Wang Zixin, Li Jiamin, Wang Xinyi et al. · Stroke · 2026
PMID: 41078125Meta-AnalysisFull text (PMC)
Alteplase versus tenecteplase in acute ischemic stroke with large vessel occlusion: a systematic review and meta-analysis.
El Din Moawad Mostafa Hossam, Serag Ibrahim, Abo Elnaga Ahmed A et al. · Eur J Clin Pharmacol · 2026
PMID: 41546719Meta-Analysis
Efficacy and safety of tenecteplase administration in extended time window for acute ischemic stroke: An updated meta-analysis of randomized controlled trials.
Ifzaal Moazzma, Bughio Sharib Afzal, Rizvi Syed Ali Farhan Abbas et al. · J Stroke Cerebrovasc Dis · 2025
PMID: 40324546Meta-Analysis
Tenecteplase versus alteplase in patients with acute ischemic stroke: An updated meta-analysis of randomized controlled trials.
Sheraz Maheen, Asif Nawal, Khan Ariba et al. · J Stroke Cerebrovasc Dis · 2025
PMID: 40157656Meta-Analysis
Risk of intracerebral haemorrhage with tenecteplase versus alteplase in acute ischaemic stroke: a meta-analysis.
Tao Min, Zhang Xiao-Han, Yan Ling-Wan et al. · J Neurol · 2025
PMID: 40208343Meta-Analysis
Tenecteplase versus alteplase in patients with acute ischemic stroke: an updated systematic review and meta-analysis.
Hagag Abdelmonam M, Kormod Muhammed E, Ads Mahmoud Elmwafy et al. · Eur J Med Res · 2025
PMID: 40775658Meta-AnalysisFull text (PMC)
Fibrinogen time course in acute ischemic stroke patients treated with intravenous thrombolysis with alteplase or tenecteplase.
Theodorou Aikaterini, Psychogios Klearchos, Kargiotis Odysseas et al. · Eur Stroke J · 2025
PMID: 40518695Meta-AnalysisFull text (PMC)
Intravenous thrombolysis with tenecteplase versus alteplase in acute ischemic stroke tandem occlusions: a systematic review and meta-analysis of current available literature.
Gonçalves Ocílio Ribeiro, Ferreira Márcio Yuri, de Almeida Monteiro Gabriel et al. · J Thromb Thrombolysis · 2025
PMID: 40082388Meta-Analysis
Efficacy and Safety of Tenecteplase in Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials.
Bacha Zaryab, Javed Javeria, Sheraz Maheen et al. · Brain Behav · 2025
PMID: 40891051Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Tenecteplase (substance)
SNOMED CT
387066007
UMLS CUI
C0872913
RxNorm CUI
259280

Clinical Data

This intervention maps to 8 entities in the Healos knowledge graph.

2
Conditions
3
Biomarkers
2
Specialists
0
Symptoms
7
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.