Substance / Medication

Thyroxine

Overview

Active Ingredient
levothyroxine
RxNorm CUI
10582

Indications

® NP Thyroidtablets (thyroid tablets, USP) are indicated: 1. As replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. This category includes cretinism, myxedema, and ordinary hypothyroidism in patients of any age (children, adults, the elderly), or state (including pregnancy); primary hypothyroidism resulting from functional deficiency, primary atrophy, partial or total absence of th

Labeler: Acella Pharmaceuticals, LLCUpdated: 2026-01-27T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

Drugs with thyroid hormone activity, alone or together with other therapeutic agents, have been used for the treatment of obesity. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threaten

Contraindications

When this intervention should not be used

Thyroid hormone preparations are generally contraindicated in patients with diagnosed but as yet uncorrected adrenal cortical insufficiency, untreated thyrotoxicosis, and apparent hypersensitivity to any of their active or extraneous constituents. There is no well-documented evidence from the litera

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

3 trials linked to this intervention

3
Total Trials
0
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Establishing the Adequate Levothyroxine Dose After Total Thyroidectomy: A Systematic Review With Meta-analysis.
Chiardi Isabella, Croce Laura, Caccavale Paolo et al. · J Clin Endocrinol Metab · 2025
PMID: 40682434Meta-AnalysisFull text (PMC)
Levothyroxine in euthyroid pregnant women with thyroid peroxidase antibody: a systematic review and meta-analysis of randomized controlled trials.
Provinciatto Henrique, Barbalho Maria Esther, da Câmara Pedro Matos et al. · Rev Bras Ginecol Obstet · 2025
PMID: 41341943Meta-AnalysisFull text (PMC)
Effectiveness of low dose thyroxine in patients with subclinical hypothyroidism and migraine; systematic review and meta-analysis.
Alokley Alia, ALNasser Maryam N, Alabdulqader Razan Anwar et al. · BMC Neurol · 2025
PMID: 40329276Meta-AnalysisFull text (PMC)
Effects of levothyroxine therapy on bone and mineral metabolism in hypothyroidism: a systematic review and meta-analysis.
Li Xiaotao, Zhang Taotao, Zhang Hongling et al. · BMC Endocr Disord · 2025
PMID: 39810175Meta-AnalysisFull text (PMC)
Therapeutic efficacy and patient compliance of levothyroxine liquid and softgel formulations taken with meals: a systematic review.
Oteri Vittorio, Volpe Salvatore, Lopes Mariarita et al. · Endocrine · 2025
PMID: 39215906Meta-AnalysisFull text (PMC)
Effect of Levothyroxine Therapy on Gestational Hypertension and Pre-eclampsia in Pregnant Women with Subclinical Hypothyroidism, Hypothyroidism, and Thyroid Autoimmunity: A Systematic Review and Meta-analysis.
Goodarzi-Khoigani Masoomeh, Aminorroaya Ashraf, Mohammadi Raziyeh · Cardiovasc Hematol Disord Drug Targets · 2025
PMID: 39976090Meta-Analysis
Effects of timing and scheduling in levothyroxine adherence to hypothyroidism control: Meta-analysis with trial sequential analysis of Randomized Clinical Trials.
da Rocha Bruno Simas, Silveira Vitor Bock, Rados Dimitris Varvaki et al. · Endocrine · 2025
PMID: 40220082Meta-Analysis
The effect of different levothyroxine administration regimens on thyroid hormone levels: a systematic review, pairwise, and network meta-analysis.
Bianchini Bianca Vendruscolo, de Jesus Patricia Romualdo, de Mello Renato Gorga Bandeira et al. · Expert Rev Clin Pharmacol · 2024
PMID: 38294680Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Thyroxine (substance)
SNOMED CT
73187006
UMLS CUI
C0040165
RxNorm CUI
10582
Labeler
Acella Pharmaceuticals, LLC

Clinical Data

This intervention maps to 7 entities in the Healos knowledge graph.

6
Conditions
1
Biomarkers
0
Specialists
0
Symptoms
3
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.