Substance / Medication

Tocilizumab

Overview

Active Ingredient
tocilizumab
RxNorm CUI
612865
Labeler: CELLTRION USA, Inc.Updated: 2026-01-23T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

Warnings and Precautions (5.1) Adverse Reactions (6.1) [see,] Patients treated with tocilizumab products including AVTOZMA are at increased risk for developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosup

Contraindications

When this intervention should not be used

Warnings and Precautions (5.6) [see]. AVTOZMA is contraindicated in patients with known hypersensitivity to tocilizumab products

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Research Evidence

Published studies and systematic reviews

Sort:
The Efficacy and Safety of Intravenous Tocilizumab to Treat Graves' Ophthalmopathy: A Systematic Review and Single-arm Meta-analysis.
Sun Aimin, Wang Xing, Qu Jinfeng et al. · J Clin Endocrinol Metab · 2025
PMID: 39401327Meta-Analysis
Comparative efficacy and safety of rituximab, tocilizumab, and teprotumumab in Graves' orbitopathy: a systematic review and meta-analysis.
Abumohssin Abdulelah G, Alshareef Rayan A, Aljohani Saja et al. · Eye (Lond) · 2025
PMID: 40404973Meta-AnalysisFull text (PMC)
Safety and efficacy of tocilizumab in COVID-19: A systematic evaluation of adverse effects and therapeutic outcomes.
AlOmeir Othman, Alhowail Ahmad H, Rabbani Syed Imam et al. · J Infect Public Health · 2025
PMID: 40614684Meta-Analysis
Efficacy and safety of Tocilizumab for thyroid eye disease: a systemic review and Meta-analysis.
Lin Shuzhen, Ou Xiaodan, Cai Liangchun et al. · J Endocrinol Invest · 2025
PMID: 40304985Meta-Analysis
Effectiveness and safety of tocilizumab in refractory noninfectious uveitis: a systematic review and meta-analysis.
Kang Huanmin, Wu Xue, Xu Hanyue et al. · Front Pharmacol · 2025
PMID: 41424786Meta-AnalysisFull text (PMC)
Could tocilizumab be used in familial Mediterranean fever? A systematic review.
Mertz Philippe, Hentgen Véronique, Georgin-Lavialle Sophie · Rheumatology (Oxford) · 2025
PMID: 38950176Meta-Analysis
Efficacy and Safety of Tocilizumab in Polymyalgia Rheumatica: A Systematic Review and Meta-Analysis.
Sharma Meha, Das Siddharth Kumar, Mohindra Ritin et al. · Int J Rheum Dis · 2025
PMID: 39895497Meta-Analysis
Tocilizumab in Patients with Systemic Sclerosis-associated Interstitial Lung Disease: A Systematic Review and Meta-Analysis.
Ghazipura Marya, Macrea Madalina, Herman Derrick et al. · Ann Am Thorac Soc · 2024
PMID: 37773003Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Tocilizumab (substance)
SNOMED CT
444648007
UMLS CUI
C1609165
RxNorm CUI
612865
Labeler
CELLTRION USA, Inc.

Clinical Data

This intervention maps to 10 entities in the Healos knowledge graph.

5
Conditions
2
Biomarkers
1
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.