Substance / Medication

Trastuzumab

Overview

Active Ingredient
trastuzumab
RxNorm CUI
224905
Labeler: Cephalon, Inc.Updated: 2025-12-22T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

32 trials linked to this intervention

32
Total Trials
23
Recruiting
9
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Pertuzumab in Combination with Trastuzumab and Docetaxel as Adjuvant Doublet Therapy for HER2-Positive Breast Cancer: A Systematic Review.
Ventura Ignacio, Salcedo Nerea Pinilla, Pérez-Bermejo Marcelino et al. · Int J Mol Sci · 2025
PMID: 40076535Meta-AnalysisFull text (PMC)
Trastuzumab deruxtecan in human epidermal growth factor receptor 2-positive breast cancer brain metastases: A systematic review and updated meta-analysis.
Michelon Isabella, Castro Caio E R, Madeira Thiago et al. · Cancer Treat Rev · 2025
PMID: 39805165Meta-Analysis
A Systematic Review of Mechanisms, Incidence, and Management of Trastuzumab Deruxtecan Induced ILD/Pneumonitis in Solid Tumors.
Liao Dehua, Zhang Jiwen, Yan Ting et al. · Drug Des Devel Ther · 2025
PMID: 40083848Meta-AnalysisFull text (PMC)
Adverse effect of trastuzumab deruxtecan in solid tumours: A systematic review and meta-analysis.
Pathak Neha, Di Iorio Massimo, Gimenez Diego Malon et al. · Crit Rev Oncol Hematol · 2025
PMID: 40466817Meta-Analysis
Safety profile of trastuzumab originator vs biosimilars: a systematic review and meta-analysis of randomized clinical trials.
Oliva Andrea, Scavone Cristina, Riccardi Consiglia et al. · Clin Transl Oncol · 2025
PMID: 39292389Meta-Analysis
Right ventricular strain as a predictor of trastuzumab-induced chemotherapy-related cardiac dysfunction: A meta-analysis.
Jain Hritvik, Ahmed Mushood, Tariq Muhammad Daoud et al. · Curr Probl Cardiol · 2025
PMID: 39528123Meta-Analysis
Exploring utilities of [ 64 Cu]Cu-DOTA-trastuzumab immunoPET in breast cancer: a systematic review and meta-analysis.
Abdlkadir Ahmed Saad, Allouzi Sudqi, Obeidat Shahed et al. · Nucl Med Commun · 2025
PMID: 39834168Meta-Analysis
Safety of Permissive Cardiotoxicity of Trastuzumab in Patients with Breast Cancer: A Systematic Review and Meta-Analysis.
Taha Amira Mohamed, Odat Ramez M, Moawad Wesam Abd El-Tawab et al. · Cardiovasc Toxicol · 2025
PMID: 40627298Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Trastuzumab (substance)
SNOMED CT
387003001
UMLS CUI
C0728747
RxNorm CUI
224905
Labeler
Cephalon, Inc.

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
32
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.