Substance / Medication

Trazodone

Overview

Active Ingredient
trazodone
RxNorm CUI
10737

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

48 trials linked to this intervention

48
Total Trials
5
Recruiting
17
With Results

Research Evidence

Published studies and systematic reviews

Sort:
The effects of trazodone exposure during pregnancy on fetal outcomes: a systematic review.
Glasgow-Osment Britney, Wahib Farah, Kassam Shama et al. · Eur J Clin Pharmacol · 2025
PMID: 40691283Meta-Analysis
Effects of Trazodone on Sleep: A Systematic Review and Meta-analysis.
Kokkali Maria, Pinioti Elisavet, Lappas Andreas S et al. · CNS Drugs · 2024
PMID: 39123094Meta-Analysis
Biochemical and Biophysical in Vitro Studies and Systematic Literature Review on the Antioxidant and Antiglycation Activities of Trazodone.
Nesterowicz Miłosz, Żendzian-Piotrowska Małgorzata, Ładny Jerzy Robert et al. · Cell Physiol Biochem · 2023
PMID: 36988041Meta-Analysis
Trazodone changed the polysomnographic sleep architecture in insomnia disorder: a systematic review and meta-analysis.
Zheng Yongliang, Lv Tian, Wu Jingjing et al. · Sci Rep · 2022
PMID: 36002579Meta-AnalysisFull text (PMC)
The effects of trazodone on human cognition: a systematic review.
Gonçalo Ana Mafalda Gonçalves, Vieira-Coelho Maria Augusta · Eur J Clin Pharmacol · 2021
PMID: 34097124Meta-AnalysisFull text (PMC)
Trazodone for the treatment of insomnia: a meta-analysis of randomized placebo-controlled trials.
Yi Xiao-Yan, Ni Shi-Fen, Ghadami Mohammad Rasoul et al. · Sleep Med · 2018
PMID: 29680424Meta-Analysis
Trazodone for agitation in dementia.
Martinon-Torres G, Fioravanti M, Grimley Evans J · Cochrane Database Syst Rev · 2004
PMID: 15495135Meta-Analysis
Trazodone for erectile dysfunction: a systematic review and meta-analysis.
Fink H A, MacDonald R, Rutks I R et al. · BJU Int · 2003
PMID: 12930437Meta-Analysis
Effect of viloxazine and trazodone in obstructive sleep apnoea: a randomised, placebo-controlled, cross-over study.
Aishah Atqiya, Kim Molly, Gell Laura et al. · Thorax · 2025
PMID: 40360261RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Trazodone (substance)
SNOMED CT
372829000
UMLS CUI
C0040805
RxNorm CUI
10737

Clinical Data

This intervention maps to 8 entities in the Healos knowledge graph.

2
Conditions
3
Biomarkers
2
Specialists
0
Symptoms
48
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.