Substance / Medication

Treprostinil

Overview

Active Ingredient
treprostinil
RxNorm CUI
343048
Labeler: United Therapeutics CorporationUpdated: 2025-11-20T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

9 trials linked to this intervention

9
Total Trials
1
Recruiting
7
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Inhaled treprostinil in pulmonary hypertension associated with COPD: PERFECT study results.
Nathan Steven D, Argula Rahul, Trivieri Maria G et al. · Eur Respir J · 2024
PMID: 38811045RCTFull text (PMC)
Oral Treprostinil is Associated with Improved Survival in FREEDOM-EV and its Open-Label Extension.
Grünig Ekkehard, Rahaghi Franck, Elwing Jean et al. · Adv Ther · 2024
PMID: 38055186RCTFull text (PMC)
Long-term inhaled treprostinil for pulmonary hypertension due to interstitial lung disease: INCREASE open-label extension study.
Waxman Aaron, Restrepo-Jaramillo Ricardo, Thenappan Thenappan et al. · Eur Respir J · 2023
PMID: 37080567RCTFull text (PMC)
Randomized, Placebo-controlled Trial of Inhaled Treprostinil for Patients at Risk for Acute Respiratory Distress Syndrome.
Ford H James, Anderson Wayne H, Wendlandt Blair et al. · Ann Am Thorac Soc · 2021
PMID: 33095030RCT
Dynamic exercise changes in venous pressure and liver stiffness in Fontan patients: effects of Treprostinil.
Possner Mathias, Chaudhry Anisa, Dillman Jonathan R et al. · Cardiol Young · 2021
PMID: 33504408RCT
Treprostinil Hydrogel Iontophoresis in Systemic Sclerosis-Related Digital Skin Ulcers: A Safety Study.
Guigui Alicia, Mazet Roseline, Blaise Sophie et al. · J Clin Pharmacol · 2020
PMID: 32080862RCT
Vascular Effects of Treprostinil Cutaneous Iontophoresis on the Leg, Finger, and Foot.
Gaillard-Bigot Florence, Roustit Matthieu, Jourdil Jean-François et al. · J Clin Pharmacol · 2017
PMID: 28387950RCT
Cutaneous iontophoresis of treprostinil, a prostacyclin analog, increases microvascular blood flux in diabetic malleolus area.
Hellmann Marcin, Roustit Matthieu, Gaillard-Bigot Florence et al. · Eur J Pharmacol · 2015
PMID: 25843412RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Treprostinil (substance)
SNOMED CT
443570007
UMLS CUI
C1145760
RxNorm CUI
343048
Labeler
United Therapeutics Corporation

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
9
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.