Substance / Medication

Tretinoin

Overview

Active Ingredient
tretinoin
RxNorm CUI
10753

Indications

(To understand fully the indication for this product, please read the entire INDICATIONS AND USAGE section of the labeling.) fine RENOVA (tretinoin cream) 0.02% DOES NOT ELIMINATE WRINKLES, REPAIR SUN-DAMAGED SKIN, REVERSE PHOTOAGING, or RESTORE MORE YOUTHFUL or YOUNGER SKIN. RENOVA (tretinoin cream) 0.02% is indicated as an adjunctive agent (see second bullet point below) for use in the mitigation (palliation) offacial wrinkles in patients who use comprehensive skin care and sunlight avoidance

Labeler: Bausch Health US LLCUpdated: 2026-02-24T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

This drug is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

106 trials linked to this intervention

106
Total Trials
6
Recruiting
66
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Systematic Review of Rare Major Adverse Cardiovascular Events Associated With the Treatment of Acne With Isotretinoin.
Cowan Timothy L, Stark Madeleine, Sarmiento Simona et al. · Australas J Dermatol · 2025
PMID: 39927601Meta-AnalysisFull text (PMC)
Low-dose isotretinoin for the management of rosacea: A systematic review and meta-analysis.
King Aliyah, Tan Marcus G, Kirshen Carly et al. · J Eur Acad Dermatol Venereol · 2025
PMID: 39239956Meta-AnalysisFull text (PMC)
Optimizing Rhinoplasty Outcomes: The Role of Isotretinoin and Patient Management Strategies: Systematic Review.
Ghazizadeh Matin, Barati Behrouz, Tabrizi Ali Goljanian et al. · J Cosmet Dermatol · 2025
PMID: 41307186Meta-AnalysisFull text (PMC)
Effects of isotretinoin on bone dynamics in the craniomaxillofacial region: a systematic review of preclinical evidence.
Ferreira M Fernanda, Nunes G Pereira, Chaves-Neto A Hernandes et al. · Eur Arch Paediatr Dent · 2025
PMID: 40924363Meta-Analysis
The role of oral nutraceuticals as adjunctive therapy to reduce side effects from isotretinoin: A systematic review.
Shields Ali, Ly Sophia, Wafae Bruna et al. · J Am Acad Dermatol · 2024
PMID: 37871802Meta-AnalysisFull text (PMC)
Combinations of Energy-based Devices plus isotretinoin for management of acne and acne scars: A systematic review.
Xu Yidan, Wang Hao, Guo Linghong et al. · J Cosmet Dermatol · 2024
PMID: 38845186Meta-Analysis
Treatment of Acute Psychosis Caused by Isotretinoin: Systematic Review.
Stanojkovic Tijana, Zivkovic Zaric Radica, Lesnjak Ivana et al. · Psychiatry Clin Psychopharmacol · 2024
PMID: 39165893Meta-AnalysisFull text (PMC)
Comparing Tretinoin to Other Topical Therapies in the Treatment of Skin Photoaging: A Systematic Review.
Siddiqui Zoya, Zufall Alina, Nash Marissa et al. · Am J Clin Dermatol · 2024
PMID: 39348007Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Tretinoin (substance)
SNOMED CT
387305002
UMLS CUI
C0040845
RxNorm CUI
10753
Labeler
Bausch Health US LLC

Clinical Data

This intervention maps to 3 entities in the Healos knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
106
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.