Substance / Medication

Triamterene

Overview

Active Ingredient
triamterene
RxNorm CUI
10763

Indications

This fixed combination drug is not indicated for the initial therapy of edema or hypertension except in individuals in whom the development of hypokalemia cannot be risked. Triamterene and hydrochlorothiazide tablets may be used alone or in combination with other antihypertensive drugs, such as beta-blockers. Since triamterene and hydrochlorothiazide may enhance the actions of these drugs, dosage adjustments may be necessary. Triamterene and hydrochlorothiazide tablets are indicated for the tre

Labeler: NuCare Pharmaceuticals,Inc.Updated: 2026-02-20T00:00:00.000ZFull label on DailyMed

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Research Evidence

Published studies and systematic reviews

Sort:
Intensive Blood Pressure Control in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Cardiovascular and Microvascular Outcomes.
Mousavi Asma, Shojaei Shayan, Abhari Amir Parsa et al. · Am J Hypertens · 2026
PMID: 40717314Meta-Analysis
The Effect of SGLT2 Inhibitors on Blood Pressure in Relation to Baseline Kidney Function: A Systematic Literature Review and Data Analysis.
Møller Charlotte Agergaard, Nielsen Steffen Flindt, Mose Frank Holden · Am J Hypertens · 2026
PMID: 40717316Meta-Analysis
Arterial spin labeling MRI in assessing cerebral blood flow changes due to hypertension: a systematic review.
Muthu Sathya Sabina, Sukumar Suresh, Kadavigere Rajagopal et al. · J Hypertens · 2026
PMID: 41002015Meta-AnalysisFull text (PMC)
The intergenerational effects of low parental socio-economic position on cardiometabolic and inflammatory outcomes: A systematic review and meta-analysis.
Rivillas-García Juan Carlos, Courtin Emilie, Winpenny Eleanor et al. · Eur J Clin Invest · 2026
PMID: 41020493Meta-AnalysisFull text (PMC)
Intake of coffee and blood pressure: A Mendelian randomized study.
Zhong Jiwen, Huang Sichao, Dong Shaohong et al. · Nutr Metab Cardiovasc Dis · 2026
PMID: 41087205Meta-Analysis
Angiotensin receptor neprilysin inhibitor for the treatment of hypertension: a systematic review and meta-analysis.
Noe Hsu Myat, Sujarit Alisara Sangviroon, Chongmelaxme Bunchai et al. · Hypertens Res · 2026
PMID: 41145713Meta-Analysis
Effects of Triamterene in Hospitalized Patients with Heart Failure and Diuretic Resistance: A Randomized Clinical Trial.
Taban-Sadeghi Mohammadreza, Khani Elnaz, Khezripour Kimia et al. · J Clin Pharmacol · 2023
PMID: 37493211RCT
Bioequivalence evaluation of a triamterene-hydrochlorothiazide generic product: a new bioequivalence index for fixed-dose combinations.
Hamidi Mehrdad, Shahbazi Mohammad-Ali, Azimi Kourosh · Regul Toxicol Pharmacol · 2011
PMID: 21193005RCT
Attenuation of the kaluretic properties of furosemide by triamterene (Dyrenium) in healthy volunteers.
Levinson B, Shenouda M, Stypinski D · Int J Clin Pharmacol Ther · 2005
PMID: 15726878Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Triamterene (substance)
SNOMED CT
387053007
UMLS CUI
C0040869
RxNorm CUI
10763
Labeler
NuCare Pharmaceuticals,Inc.

Clinical Data

This intervention maps to 8 entities in the Ltrl knowledge graph.

2
Conditions
3
Biomarkers
2
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.