Substance / Medication

Trimethadione

Overview

Active Ingredient
trimethadione
RxNorm CUI
10827

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

91 trials linked to this intervention

91
Total Trials
16
Recruiting
33
With Results

Research Evidence

Published studies and systematic reviews

Sort:
The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil.
Barton Matthew E, Eberle Elizabeth L, Shannon Harlan E · Eur J Pharmacol · 2005
PMID: 16171802Observational
[Fetal trimethadione syndrome].
Nagai T · Ryoikibetsu Shokogun Shirizu · 2001
PMID: 11462643Review
[Fetal trimethadione effects].
Nakane Y · Ryoikibetsu Shokogun Shirizu · 2000
PMID: 11057156Review
Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes.
Tanaka E, Kurata N, Yasuhara H · J Clin Pharm Ther · 2003
PMID: 14651673Other
Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides.
Pastore Valentina, Sabatier Laureano, Enrique Andrea et al. · Bioorg Med Chem · 2013
PMID: 23321016Preclinical
[Toxic effects of trimethadione on zebrafish early development].
Qin Wei, Hu Zhan-Ying, Tong Jun-Wei et al. · Yi Chuan · 2012
PMID: 23017458Preclinical
Postnatal closure of membranous ventricular septal defects in Sprague-Dawley rat pups after maternal exposure with trimethadione.
Fleeman Tammye L, Cappon Gregg D, Hurtt Mark E · Birth Defects Res B Dev Reprod Toxicol · 2004
PMID: 15282739Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Trimethadione (substance)
SNOMED CT
70732003
UMLS CUI
C0041038
RxNorm CUI
10827

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
91
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.

Trimethadione — Conditions, Biomarkers & Specialists | Healos | Healos