Substance / Medication

Tris(hydroxymethyl)aminomethane

Overview

Active Ingredient
tromethamine
RxNorm CUI
10865

Indications

Tromethamine Injection is indicated for the prevention and correction of metabolic acidosis. In the following conditions it may help to sustain vital functions and thus provide time for treatment of the primary disease: Metabolic Acidosis Associated with Cardiac Bypass Surgery. Tromethamine Injection has been found to be primarily beneficial in correcting metabolic acidosis which may occur during or immediately following cardiac bypass surgical procedures. Correction of Acidity of ACD Blood in C

Labeler: MILLA PHARMACEUTICALS INC.Updated: 2026-01-07T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Tromethamine Injection is contraindicated in uremia and anuria. In neonates it is also contraindicated in chronic respiratory acidosis and salicylate intoxication.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

7 trials linked to this intervention

7
Total Trials
2
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Plastic phase transitions in tris(hydroxymethyl)aminomethane perchlorate.
Zhou Feng, Weng Yan-Ran, Shi Yu et al. · Dalton Trans · 2024
PMID: 38647331Other
Breakthrough Curve Modeling and Analysis for Lysozyme Adsorption by Tris(hydroxymethyl)aminomethane Affinity Nanofiber Membrane.
Chen Kuei-Hsiang, Lai You-Ren, Hanh Nguyen The Duc et al. · Membranes (Basel) · 2023
PMID: 37755183OtherFull text (PMC)
Crystal structure of Sphingobacterium multivorum serine palmitoyltransferase complexed with tris(hydroxymethyl)aminomethane.
Ikushiro Hiroko, Takahashi Aya, Murakami Taiki et al. · Acta Crystallogr F Struct Biol Commun · 2022
PMID: 36458620OtherFull text (PMC)
Tris(hydroxymethyl)aminomethane Compatibility with-Hydroxysuccinimide Ester Chemistry: Biotinylation of Peptides and Proteins in TRIS Buffer.
Kratzer Ulrich, Sommersdorf Cornelia, Maier Sandra et al. · Bioconjug Chem · 2021
PMID: 34406760Other

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Trometamol (substance)
SNOMED CT
59034000
UMLS CUI
C0041175
RxNorm CUI
10865
Labeler
MILLA PHARMACEUTICALS INC.

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
7
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.