Substance / Medication

Ublituximab

Overview

Active Ingredient
ublituximab
RxNorm CUI
2626349

Indications

BRIUMVI is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Labeler: TG Therapeutics, Inc.Updated: 2026-02-19T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

BRIUMVI is contraindicated in patients with: Dosage and Administration (2.1) Warnings and Precautions (5.2) [seeand] Active HBV infection Warnings and Precautions (5.1) [see] A history of life-threatening infusion reaction to BRIUMVI

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

2 trials linked to this intervention

2
Total Trials
2
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Outcomes of Ublituximab compared to Teriflunomide for relapsing multiple sclerosis: A meta-analysis.
Mukhtar Humza, Yasmeen Uzma, Siddiqa Sania et al. · Mult Scler Relat Disord · 2022
PMID: 35779372Meta-Analysis
The ULTIMATE trials: are there advantages of ublituximab over teriflunomide in relapsing multiple sclerosis?
Doggrell Sheila A · Expert Opin Biol Ther · 2022
PMID: 36317532Meta-Analysis
Preclinical study of Ublituximab, a Glycoengineered anti-human CD20 antibody, in murine models of primary cerebral and intraocular B-cell lymphomas.
Ben Abdelwahed Rym, Donnou Sabrina, Ouakrim Hanane et al. · Invest Ophthalmol Vis Sci · 2013
PMID: 23611989Observational
Switching to ublituximab from prior anti-CD20 monoclonal antibody therapy: a case report series.
Berkovich Regina, Calkwood Jonathan, Crayton Heidi et al. · Front Immunol · 2025
PMID: 40255393Case ReportFull text (PMC)
Efficacy and safety of ublituximab for relapsing multiple sclerosis patients: current evidence and expert opinion.
Preziosa Paolo, Brescia Morra Vincenzo, Capobianco Marco et al. · J Neurol · 2025
PMID: 41107611ReviewFull text (PMC)
Real-world safety assessment of ublituximab: a pharmacovigilance analysis based on the FDA adverse event reporting system.
Luo Sen, Feng Yining, Huang Zhuo et al. · Int J Clin Pharm · 2025
PMID: 41118058Other
Pharmacodynamics and Pharmacokinetics of Ublituximab Compared with Other Anti-Cd20 Monoclonal Antibodies for Multiple Sclerosis Treatment.
Margoni Monica, Battistini Luca, Centonze Diego et al. · Curr Neuropharmacol · 2025
PMID: 40873276Other
Modeling lymphocyte subset dynamics after ublituximab therapy in patients with multiple sclerosis: an Italian prospective study.
Zanghì Aurora, Di Filippo Paola Sofia, Papale Massimo et al. · Front Immunol · 2025
PMID: 41357224OtherFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Ublituximab (substance)
SNOMED CT
1351582007
UMLS CUI
C4083151
RxNorm CUI
2626349
Labeler
TG Therapeutics, Inc.

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
2
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.