Substance / Medication

Valproate

Overview

Active Ingredient
valproate
RxNorm CUI
40254

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

91 trials linked to this intervention

91
Total Trials
16
Recruiting
33
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Phenobarbital versus valproate for generalized convulsive status epilepticus in adults. An updated systematic review and meta-analysis.
Haq Umair Ul, Majeed Neha, Kumari Nisha et al. · Epilepsy Res · 2025
PMID: 40349574Meta-Analysis
Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic Review.
Camussi Diletta, Marchese Maria, Nicoletti Ferdinando et al. · Cells · 2025
PMID: 39851536Meta-AnalysisFull text (PMC)
Valproate Exposure as anModel for Studying Morpho-Molecular Features of ASD: A Systematic Review.
Vasconcelos Quezia Damaris Jones Severino, Serafini Michele Aramburu, Carletti Jaqueline Vieira et al. · CNS Neurol Disord Drug Targets · 2025
PMID: 40296624Meta-Analysis
Gestational Exposure to Valproate and Autism Spectrum Disorder or Attention-Deficit/Hyperactivity Disorder in Offspring: Systematic Review and Meta-Analysis.
Andrade Chittaranjan, Varadharajan Natarajan, Bascarane Sharmi et al. · Acta Psychiatr Scand · 2025
PMID: 40059353Meta-Analysis
Comparative Risk of Major Congenital Malformations With Antiseizure Medication Combinations vs Valproate Monotherapy in Pregnancy.
Cohen Jacqueline M, Alvestad Silje, Suarez Elizabeth A et al. · Neurology · 2024
PMID: 38165339Meta-AnalysisFull text (PMC)
Subcutaneous sodium valproate in palliative care: A systematic review.
Tan Sheryn, Ng Jeng Swen, Tang Charis et al. · Palliat Med · 2024
PMID: 38444061Meta-AnalysisFull text (PMC)
Understanding the impact of valproate on male fertility: insights from preclinical and clinical meta-analysis.
Asghar Muhammad Arif, Tang Shixin, Wan Bing et al. · BMC Pharmacol Toxicol · 2024
PMID: 39334455Meta-AnalysisFull text (PMC)
Systematic Review and Meta-Analysis of Salt Valproate Preventing Switch Associated with Antidepressants in Chinese Patients With Depressive Episodes.
Dong Shen, Lv Wangqiang, Fengli Sun et al. · Altern Ther Health Med · 2023
PMID: 36634315Meta-Analysis
Effects of magnesium valproate adjuvant therapy on patients with dementia: A systematic review and meta-analysis.
Zhang ChenQi, Sun LingQi, Sun HongBin · Medicine (Baltimore) · 2022
PMID: 35945786Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Valproate (substance)
SNOMED CT
264325000
UMLS CUI
C0080356
RxNorm CUI
40254

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
91
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.

Valproate — Conditions, Biomarkers & Specialists | Healos | Healos