Substance / Medication

Vigabatrin

Overview

Active Ingredient
vigabatrin
RxNorm CUI
14851
Labeler: Carnegie Pharmaceuticals LLCUpdated: 2026-02-17T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

Viga 5.1 [see Warnings and Precautions ()] batrin can cause permanent bilateral concentric visual field constriction, including tunnel vision that can result in disability. In some cases, vigabatrin also can damage the central retina and may decrease visual acuity. The onset of vision loss from viga

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

91 trials linked to this intervention

91
Total Trials
16
Recruiting
33
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy of vigabatrin in the treatment of infantile epileptic spasms syndrome: A systematic review and meta-analysis.
Xu Zhao, Gong Pan, Jiao Xianru et al. · Epilepsia Open · 2023
PMID: 36740237Meta-AnalysisFull text (PMC)
Vigabatrin-related adverse events for the treatment of epileptic spasms: systematic review and meta-analysis.
Biswas Asthik, Yossofzai Omar, Vincent Ajoy et al. · Expert Rev Neurother · 2020
PMID: 33078964Meta-Analysis
Vigabatrin add-on therapy for drug-resistant focal epilepsy.
Bresnahan Rebecca, Gianatsi Myrsini, Maguire Melissa J et al. · Cochrane Database Syst Rev · 2020
PMID: 32730657Meta-AnalysisFull text (PMC)
Reduction of retinal nerve fiber layer thickness in vigabatrin-exposed patients: A meta-analysis.
Peng Yingqian, Zhao Yinan, Hu Wenyu et al. · Clin Neurol Neurosurg · 2017
PMID: 28412542Meta-Analysis
Vigabatrin versus carbamazepine monotherapy for epilepsy.
Xiao Yousheng, Gan Lu, Wang Jin et al. · Cochrane Database Syst Rev · 2015
PMID: 26580100Meta-AnalysisFull text (PMC)
Vigabatrin for refractory partial epilepsy.
Hemming Karla, Maguire Melissa J, Hutton Jane L et al. · Cochrane Database Syst Rev · 2013
PMID: 23440814Meta-Analysis
Vigabatrin versus carbamazepine monotherapy for epilepsy.
Xiao Yousheng, Gan Lu, Wang Jin et al. · Cochrane Database Syst Rev · 2012
PMID: 22258989Meta-Analysis
Vigabatrin for refractory partial epilepsy.
Hemming Karla, Maguire Melissa J, Hutton Jane L et al. · Cochrane Database Syst Rev · 2008
PMID: 18646179Meta-Analysis
Combination Therapy With Vigabatrin and Prednisolone Versus Vigabatrin Alone for Infantile Spasms.
Boonkrongsak Rachata, Trongkamolchai Kantapon, Suwannachote Sirorat et al. · Ann Clin Transl Neurol · 2025
PMID: 40116235RCTFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Vigabatrin (substance)
SNOMED CT
310283001
UMLS CUI
C0048044
RxNorm CUI
14851
Labeler
Carnegie Pharmaceuticals LLC

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
91
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.

Vigabatrin — Conditions, Biomarkers & Specialists | Healos | Healos